Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
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Wnt4 participates in the formation of vertebrate neuromuscular junctionCharcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levelsForm and function: the laminin family of heterotrimersSyne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junctionA single pulse of agrin triggers a pathway that acts to cluster acetylcholine receptorsAgrin is a major heparan sulfate proteoglycan in the human glomerular basement membraneControl of rapsyn stability by the CUL-3-containing E3 ligase complexAgrin binds to the nerve-muscle basal lamina via lamininNeurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2.Rapsyn mutations in humans cause endplate acetylcholine-receptor deficiency and myasthenic syndromeTo build a synapse: signaling pathways in neuromuscular junction assemblyThe dystroglycan complex is necessary for stabilization of acetylcholine receptor clusters at neuromuscular junctions and formation of the synaptic basement membraneDistinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializationsPerlecan maintains the integrity of cartilage and some basement membranesSubendothelial heparan sulfate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusionAbsence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophinUltrastructure of acetylcholine receptor aggregates parallels mechanisms of aggregationMechanistic distinctions between agrin and laminin-1 induced aggregation of acetylcholine receptorsNeuromuscular Junctions as Key Contributors and Therapeutic Targets in Spinal Muscular AtrophyHeparan sulfate proteoglycans: a sugar code for vertebrate development?The Wnt and BMP families of signaling morphogens at the vertebrate neuromuscular junctionProtein composition and biomechanical properties of in vivo-derived basement membranesCrosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junctionImpaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration.The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctionsNovel mouse model reveals distinct activity-dependent and -independent contributions to synapse developmentCrystal Structure of the Frizzled-Like Cysteine-Rich Domain of the Receptor Tyrosine Kinase MuSKStructural basis of agrin-LRP4-MuSK signalingThe role of agrin in synaptic development, plasticity and signaling in the central nervous systemThe neurogenetics of alternative splicingReceptor tyrosine kinase signaling: regulating neural crest development one phosphate at a timeCloning and expression of full length mouse utrophin: the differential association of utrophin and dystrophin with AChR clustersCongenital myasthenic syndromes due to heteroallelic nonsense/missense mutations in the acetylcholine receptor epsilon subunit gene: identification and functional characterization of six new mutationsCostameric proteins in human skeletal muscle during muscular inactivityAcetylcholine receptors are required for agrin-induced clustering of postsynaptic proteins.Agrin is a chimeric proteoglycan with the attachment sites for heparan sulfate/chondroitin sulfate located in two multiple serine-glycine clustersAgrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinaseLrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapsesLRP4 serves as a coreceptor of agrin
P2860
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P2860
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
description
1996 nî lūn-bûn
@nan
1996 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
@ast
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
@en
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
@nl
type
label
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
@ast
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
@en
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
@nl
prefLabel
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
@ast
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
@en
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
@nl
P2093
P3181
P1433
P1476
Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
@en
P2093
P304
P3181
P356
10.1016/S0092-8674(00)81253-2
P407
P577
1996-05-01T00:00:00Z