MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response
about
PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesisβ-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activationMetastasis-associated protein 1 is an integral component of the circadian molecular machineryReduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibitionComprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing.Identification of novel gene targets and functions of p21-activated kinase 1 during DNA damage by gene expression profilingDysregulation of PAK1 Is Associated with DNA Damage and Is of Prognostic Importance in Primary Esophageal Small Cell Carcinoma.By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.MORC2 mutations cause axonal Charcot-Marie-Tooth disease with pyramidal signs.The MORC family: new epigenetic regulators of transcription and DNA damage response.Topoisomerase II beta interacts with cohesin and CTCF at topological domain bordersCytosolic functions of MORC2 in lipogenesis and adipogenesisIdentification of key pathways and genes influencing prognosis in bladder urothelial carcinomaDNA Damage Repair in the Context of Plant Chromatin.Transcriptional regulation of ataxia-telangiectasia and Rad3-related protein by activated p21-activated kinase-1 protects keratinocytes in UV-B-induced premalignant skin lesions.Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.P21-activated kinase 1 (Pak1) signaling influences therapeutic outcome in pancreatic cancer.Structure, biochemistry, and biology of PAK kinases.The Emerging Role of MORC Family Proteins in Cancer Development and Bone Homeostasis.E2F-7 couples DNA damage-dependent transcription with the DNA repair process.Signaling coupled epigenomic regulation of gene expression.MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus.Chromatin remodeling protein MORC2 promotes breast cancer invasion and metastasis through a PRD domain-mediated interaction with CTNND1.High intra-familiar clinical variability in MORC2 mutated CMT2 patients.MORC2B is essential for meiotic progression and fertility.MORC2 mutation causes severe spinal muscular atrophy-phenotype, cerebellar atrophy, and diaphragmatic paralysis.MORC2 mutations in a cohort of Chinese patients with Charcot-Marie-Tooth disease type 2.Clinico-genetics in Korean Charcot-Marie-Tooth disease type 2Z with MORC2 mutations.Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.Mutations in the MORC2 gene cause axonal Charcot-Marie-Tooth disease.De novo p.T362R mutation in MORC2 causes early onset cerebellar ataxia, axonal polyneuropathy and nocturnal hypoventilation.MCM3AP in recessive Charcot-Marie-Tooth neuropathy and mild intellectual disability.MORC2, a novel oncogene, is upregulated in liver cancer and contributes to proliferation, metastasis and chemoresistance.Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery
P2860
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P2860
MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
MORC2 signaling integrates pho ...... during the DNA damage response
@ast
MORC2 signaling integrates pho ...... during the DNA damage response
@en
MORC2 signaling integrates pho ...... during the DNA damage response
@nl
type
label
MORC2 signaling integrates pho ...... during the DNA damage response
@ast
MORC2 signaling integrates pho ...... during the DNA damage response
@en
MORC2 signaling integrates pho ...... during the DNA damage response
@nl
prefLabel
MORC2 signaling integrates pho ...... during the DNA damage response
@ast
MORC2 signaling integrates pho ...... during the DNA damage response
@en
MORC2 signaling integrates pho ...... during the DNA damage response
@nl
P2093
P2860
P921
P3181
P1433
P1476
MORC2 signaling integrates pho ...... during the DNA damage response
@en
P2093
Anupam Kumar
Da-Qiang Li
Jeyanthy Eswaran
Kazufumi Ohshiro
Rajendra P Gajula
Rakesh Kumar
Sirigiri Divijendra Natha Reddy
Sujit S Nair
Suresh B Pakala
Vasudha S Nair
P2860
P304
P3181
P356
10.1016/J.CELREP.2012.11.018
P407
P577
2012-12-27T00:00:00Z