The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
about
Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signalingp56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transductionAdaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cellsAngiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradationDok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak.PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.A gene for inherited cutaneous venous anomalies ("glomangiomas") localizes to chromosome 1p21-22.Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signalingCharacterization of a novel member of the DOK family that binds and modulates Abl signalingBiologic significance of angiopoietin-2 expression in human hepatocellular carcinomaA unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and functionNovel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiationSustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesisA mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding proteinDok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganizationGab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signalingFiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesGab3, a new DOS/Gab family member, facilitates macrophage differentiation.p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and NckA novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signalingNck adapter proteins: functional versatility in T cellsTyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation.Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling.Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays.Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons.The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1Growth factor signaling pathways in vascular development.Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis.Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.Expression of Gab1 lacking the pleckstrin homology domain is associated with neoplastic progression.DOK4 and DOK5: new Dok-related genes expressed in human T cells.Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.Adaptors as central mediators of signal transduction in immune cells.Targeting the Tie2/Tek receptor in astrocytomas.A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice.Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformationAngiopoietin-1 causes reversible degradation of the portal microcirculation in mice: implications for treatment of liver disease.
P2860
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P2860
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
description
1998 nî lūn-bûn
@nan
1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
@ast
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
@en
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
@nl
type
label
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
@ast
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
@en
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
@nl
prefLabel
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
@ast
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
@en
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
@nl
P356
P1433
P1476
The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1202115
P407
P577
1998-09-03T00:00:00Z
P5875
P6179
1027915200