Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras
about
Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunitEvidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinasesThe Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions.Regulation of glioma cell migration by serine-phosphorylated P311Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteinsFocal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cellsGreen fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand bindingDisruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performanceNischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migrationIntegrin function: molecular hierarchies of cytoskeletal and signaling moleculesQuantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal.Disruption of C-terminal cytoplasmic domain of betaPS integrin subunit has dominant negative properties in developing Drosophila.Perturbation of beta1-integrin function alters the development of murine mammary gland.Quantitative morphodynamics of endothelial cells within confluent cultures in response to fluid shear stressTyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin.Integrin beta 1 cytoplasmic domain dominant negative effects revealed by lysophosphatidic acid treatment.The adaptor Grb7 links netrin-1 signaling to regulation of mRNA translation.Beta1C integrin in epithelial cells correlates with a nonproliferative phenotype: forced expression of beta1C inhibits prostate epithelial cell proliferation.Down-regulation of beta 1C integrin, an inhibitor of cell proliferation, in prostate carcinomaRequirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.Dominant-negative effect on adhesion by myelin Po protein truncated in its cytoplasmic domain.Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinaseInduction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function.Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation.Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitroA recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins.beta1-integrin cytoplasmic subdomains involved in dominant negative function.Use of a beta1 integrin-deficient human T cell to identify beta1 integrin cytoplasmic domain sequences critical for integrin function.Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing.Different adhesion properties of highly and poorly metastatic HT-29 colon carcinoma cells with extracellular matrix components: role of integrin expression and cytoskeletal components.The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes.Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylation.beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoterRegulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction.Beta 8 integrins mediate interactions of chick sensory neurons with laminin-1, collagen IV, and fibronectin.Uncoupling integrin adhesion and signaling: the betaPS cytoplasmic domain is sufficient to regulate gene expression in the Drosophila embryo.Targeted focal adhesion kinase activation in cardiomyocytes protects the heart from ischemia/reperfusion injuryTransmembrane-truncated alphavbeta3 integrin retains high affinity for ligand binding: evidence for an 'inside-out' suppressor?Effects of CD49d-targeted antisense-oligonucleotide on α4 integrin expression and function of acute lymphoblastic leukemia cells: Results of in vitro and in vivo studies.
P2860
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P2860
Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Transmembrane signal transduct ...... sed in single-subunit chimeras
@ast
Transmembrane signal transduct ...... sed in single-subunit chimeras
@en
Transmembrane signal transduct ...... sed in single-subunit chimeras
@nl
type
label
Transmembrane signal transduct ...... sed in single-subunit chimeras
@ast
Transmembrane signal transduct ...... sed in single-subunit chimeras
@en
Transmembrane signal transduct ...... sed in single-subunit chimeras
@nl
prefLabel
Transmembrane signal transduct ...... sed in single-subunit chimeras
@ast
Transmembrane signal transduct ...... sed in single-subunit chimeras
@en
Transmembrane signal transduct ...... sed in single-subunit chimeras
@nl
P2093
P1476
Transmembrane signal transduct ...... sed in single-subunit chimeras
@en
P2093
Akiyama SK
LaFlamme SE
P304
15961-15964
P407
P577
1994-06-01T00:00:00Z