The thiolase superfamily: condensing enzymes with diverse reaction specificities
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Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies.The sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzymeCrystal Structure of a Monomeric Thiolase-Like Protein Type 1 (TLP1) from Mycobacterium smegmatisA ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesisCrystal Structures of Xanthomonas campestris OleA Reveal Features That Promote Head-to-Head Condensation of Two Long-Chain Fatty AcidsCrystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loopThe crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activitiesThe SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolismA thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol.Structure, function, and insights into the biosynthesis of a head-to-head hydrocarbon in Shewanella oneidensis strain MR-1.Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway.Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals.Enzymes of the mevalonate pathway of isoprenoid biosynthesisPurification and characterization of OleA from Xanthomonas campestris and demonstration of a non-decarboxylative Claisen condensation reaction.Thiolase engineering for enhanced butanol production in Clostridium acetobutylicum.Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis.FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosisCoenzyme A-free activity, crystal structure, and rational engineering of a promiscuous β-ketoacyl thiolase from Ralstonia eutropha.A computationally simplistic poly-phasic approach to explore microbial communities from the Yucatan aquifer as a potential sources of novel natural products.Functional characterization of thiolase-encoding genes from Xanthophyllomyces dendrorhous and their effects on carotenoid synthesisComparative genomics analysis of Lactobacillus species associated with weight gain or weight protection.Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.Stereocontrol within polyketide assembly lines.Biosynthesis and function of bacterial dialkylresorcinol compounds.Biosynthesis of polyketides by trans-AT polyketide synthases.Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.Type III Polyketide Synthases: Functional Classification and Phylogenomics.Barth Syndrome: Connecting Cardiolipin to Cardiomyopathy.Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch.Identification of bypass reactions leading to the formation of one central steroid degradation intermediate in metabolism of different bile salts in Pseudomonas sp. strain Chol1.Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1.Structural basis of head to head polyketide fusion by CorB.Widespread head-to-head hydrocarbon biosynthesis in bacteria and role of OleA.The essential function of genes for a hydratase and an aldehyde dehydrogenase for growth of Pseudomonas sp. strain Chol1 with the steroid compound cholate indicates an aldolytic reaction step for deacetylation of the side chainCloning, expression, purification and preliminary X-ray diffraction studies of a putative Mycobacterium smegmatis thiolase.A novel and widespread class of ketosynthase is responsible for the head-to-head condensation of two acyl moieties in bacterial pyrone biosynthesis.PpORS, an ancient type III polyketide synthase, is required for integrity of leaf cuticle and resistance to dehydration in the moss, Physcomitrella patens.OleA Glu117 is key to condensation of two fatty-acyl coenzyme A substrates in long-chain olefin biosynthesis.Substrate Trapping in Crystals of the Thiolase OleA Identifies Three Channels That Enable Long Chain Olefin Biosynthesis.The phylogenomic roots of modern biochemistry: origins of proteins, cofactors and protein biosynthesis.
P2860
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P2860
The thiolase superfamily: condensing enzymes with diverse reaction specificities
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2006 nî lūn-bûn
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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
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2006年論文
@zh-hant
2006年論文
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2006年論文
@zh-mo
2006年論文
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2006年论文
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name
The thiolase superfamily: condensing enzymes with diverse reaction specificities
@ast
The thiolase superfamily: condensing enzymes with diverse reaction specificities
@en
The thiolase superfamily: condensing enzymes with diverse reaction specificities
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type
label
The thiolase superfamily: condensing enzymes with diverse reaction specificities
@ast
The thiolase superfamily: condensing enzymes with diverse reaction specificities
@en
The thiolase superfamily: condensing enzymes with diverse reaction specificities
@nl
prefLabel
The thiolase superfamily: condensing enzymes with diverse reaction specificities
@ast
The thiolase superfamily: condensing enzymes with diverse reaction specificities
@en
The thiolase superfamily: condensing enzymes with diverse reaction specificities
@nl
P2093
P1476
The thiolase superfamily: condensing enzymes with diverse reaction specificities
@en
P2093
Antti M Haapalainen
Gitte Meriläinen
Rik K Wierenga
P356
10.1016/J.TIBS.2005.11.011
P407
P577
2006-01-01T00:00:00Z