G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms
about
Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.Discovery and Development of Small Molecule Allosteric Modulators of Glycoprotein Hormone ReceptorsThe Camerino symposium series (1978-2013): a privileged observatory of receptorology developmentDiversity and modularity of G protein-coupled receptor structuresDrugs for allosteric sites on receptorsNon-traditional roles of G protein-coupled receptors in basic cell biologyA linear framework for time-scale separation in nonlinear biochemical systemsMolecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor InternalisationThe antipsychotic potential of muscarinic allosteric modulationAllosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's diseaseDeterminants involved in subtype-specific functions of rat trace amine-associated receptors 1 and 4The power of mass spectrometry in structural characterization of GPCR signaling.Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinSubstituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction.N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats.Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonistDifferential fibroblast growth factor 8 (FGF8)-mediated autoregulation of its cognate receptors, Fgfr1 and Fgfr3, in neuronal cell linesV1b and CRHR1 receptor heterodimerization mediates synergistic biological actions of vasopressin and CRH.The FMRFamide-Like Peptide Family in NematodesProfiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-à-go-go related gene potassium channels.Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Functionalized congener approach to the design of ligands for G protein-coupled receptors (GPCRs).2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites.Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1).Increased G protein-coupled receptor kinase (GRK) expression in the anterior cingulate cortex in schizophreniaAllosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor.Agnostic about in vivo inverse agonism of agouti-related peptide.Enhanced potency of nucleotide-dendrimer conjugates as agonists of the P2Y14 receptor: multivalent effect in G protein-coupled receptor recognition.Discovery Of An Orexin Receptor Positive PotentiatorAllosteric modulation of the M₃ muscarinic receptor by amiodarone and N-ethylamiodarone: application of the four-ligand allosteric two-state model.The significance of G protein-coupled receptor crystallography for drug discovery.Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryComputational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled ReceptorsAllosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin.Nanoagonist-mediated endothelial tight junction opening: A strategy for safely increasing brain drug delivery in mice.Melanotropins as drugs for the treatment of obesity and other feeding disorders: potential and problems.Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor
P2860
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P2860
G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms
@ast
G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms
@en
G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms
@nl
type
label
G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms
@ast
G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms
@en
G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms
@nl
prefLabel
G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms
@ast
G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms
@en
G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms
@nl
P3181
P356
P1433
P1476
G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms
@en
P2093
Thomas M Bridges
P304
P3181
P356
10.1021/CB800116F
P407
P577
2008-09-19T00:00:00Z