A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
about
The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase deltaDNA polymerase delta in DNA replication and genome maintenanceProteolysis of the human DNA polymerase delta smallest subunit p12 by μ-calpain in calcium-triggered apoptotic HeLa cellsDNA polymerases at the eukaryotic fork-20 years laterThe Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δDNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δPDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δA novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phaseThe tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progressionDNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primersProduction of recombinant human DNA polymerase delta in a Bombyx mori bioreactorDegradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage.DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.Ultraviolet radiation stress triggers the down-regulation of essential replication factor Mcm10.The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis.P50, the small subunit of DNA polymerase delta, is required for mediation of the interaction of polymerase delta subassemblies with PCNA.Characterization of human DNA polymerase delta and its subassemblies reconstituted by expression in the MultiBac systemSpatiotemporal recruitment of human DNA polymerase delta to sites of UV damage.Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometryExpression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21(WAF1), Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cellsCRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.Identification of RNF8 as a ubiquitin ligase involved in targeting the p12 subunit of DNA polymerase δ for degradation in response to DNA damage4-Nitroquinoline-1-oxide effects human lung adenocarcinoma A549 cells by regulating the expression of POLD4.Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis.Validating the disruption of proliferating cell nuclear antigen interactions in the development of targeted cancer therapeutics.Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis.Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ.Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 1: post-translational regulation.Regulation of human DNA polymerase delta in the cellular responses to DNA damage.Comparative proteomics analysis of global cellular stress responses to hydroxyurea-induced DNA damage in HeLa cells.POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologiesPCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions.Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases.Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases.Regulation and Modulation of Human DNA Polymerase δ Activity and Function.Differential requirements for H/ACA ribonucleoprotein components in cell proliferation and response to DNA damage.p15PAF binding to PCNA modulates the DNA sliding surface
P2860
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P2860
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
@ast
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
@en
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
@nl
type
label
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
@ast
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
@en
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
@nl
prefLabel
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
@ast
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
@en
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
@nl
P2093
P2860
P356
P1476
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta
@en
P2093
Ernest Y C Lee
Marietta Y W T Lee
Sandra Trusa
Sufang Zhang
Yajing Zhou
P2860
P304
P356
10.1074/JBC.M610356200
P407
P577
2007-05-25T00:00:00Z