Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease - Wikidata - wikimedia - TriplyDB

Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease

Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease

http://www.wikidata.org/entity/Q28290730

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Emerging drug targets for Aβ and tau in Alzheimer's disease: a systematic review Structure of the mitochondrial translocator protein in complex with a diagnostic ligand Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice.Estradiol modulates translocator protein (TSPO) and steroid acute regulatory protein (StAR) via protein kinase A (PKA) signaling in hypothalamic astrocytes Positron emission tomography and functional characterization of a complete PBR/TSPO knockout.Translocator protein (TSPO) role in aging and Alzheimer's disease.Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile.Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration.Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research.Preface.Cerebrovascular and microglial states are not altered by functional neuroinflammatory gene variant.Expression of Phenotypic Astrocyte Marker Is Increased in a Transgenic Mouse Model of Alzheimer's Disease versus Age-Matched Controls: A Presymptomatic Stage Study.Lentiviral-Mediated Overexpression of the 18 kDa Translocator Protein (TSPO) in the Hippocampal Dentate Gyrus Ameliorates LPS-Induced Cognitive Impairment in Mice.Sex and the development of Alzheimer's disease.The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus.Identification of a key cholesterol binding enhancement motif in translocator protein 18 kDa.Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina Calcium regulation of neural rhythms, memory and Alzheimer's disease.The translocator protein as a drug target in Alzheimer's disease.Lost in translocation: the functions of the 18-kD translocator protein.4'-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation.TSPO ligand residence time influences human glioblastoma multiforme cell death/life balance.Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Translocator protein 18 kDa negatively regulates inflammation in microglia.Investigation of TSPO variants in schizophrenia and antipsychotic treatment outcomes.Advances in positron emission tomography for the imaging of rheumatoid arthritis.Transethnic genome-wide scan identifies novel Alzheimer's disease loci.Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans.Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats.[125 I]IodoDPA-713 Binding to 18 kDa Translocator Protein (TSPO) in a Mouse Model of Intracerebral Hemorrhage: Implications for Neuroimaging.Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease Modulation of three key innate immune pathways for the most common retinal degenerative diseases

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Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease

http://www.wikidata.org/entity/Q28290730

description

2013 nî lūn-bûn

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2013年の論文

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Ligand for translocator protei ...... e model of Alzheimer's disease

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Ligand for translocator protei ...... e model of Alzheimer's disease

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Ligand for translocator protei ...... e model of Alzheimer's disease

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Ligand for translocator protei ...... e model of Alzheimer's disease

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Ligand for translocator protei ...... e model of Alzheimer's disease

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Ligand for translocator protei ...... e model of Alzheimer's disease

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Ligand for translocator protei ...... e model of Alzheimer's disease

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Ligand for translocator protei ...... e model of Alzheimer's disease

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JNEUROSCI.1350-13.2013

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Journal of Neuroscience

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Ligand for translocator protei ...... e model of Alzheimer's disease

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Anusha Jayaraman

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Donatella Caruso

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Joo-Won Lee

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P2860

Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies

Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotrauma

Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects

Microglia-specific localisation of a novel calcium binding protein, Iba1

Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease

A beta oligomers - a decade of discovery

Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review.

Attention and executive deficits in Alzheimer's disease. A critical review.

Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice.

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10.1523/JNEUROSCI.1350-13.2013

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Luis Miguel Garcia-Segura

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Roberto Cosimo Melcangi

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23678130

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Alzheimer's disease

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3733563

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