Complete phenotypic characterization of apobec-1 knockout mice with a wild-type genetic background and a human apolipoprotein B transgenic background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of Apobec-1

Complete phenotypic characterization of apobec-1 knockout mice with a wild-type genetic background and a human apolipoprotein B transgenic background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of Apobec-1

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http://www.wikidata.org/entity/Q28291031

Q28291031

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Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality Mouse and other rodent models of C to U RNA editing A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits RNA Editing-Systemic Relevance and Clue to Disease Mechanisms?Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts Retroviral restriction by APOBEC proteins Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice Superior role of apolipoprotein B48 over apolipoprotein B100 in chylomicron assembly and fat absorption: an investigation of apobec-1 knock-out and wild-type mice C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47 Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.Functions and regulation of the APOBEC family of proteins Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid composition in mice High-resolution genetic mapping in the diversity outbred mouse population identifies Apobec1 as a candidate gene for atherosclerosis.APOBEC-1-mediated RNA editing.Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome.Apolipoprotein B48, the Structural Component of Chylomicrons, Is Sufficient to Antagonize Staphylococcus aureus Quorum-Sensing.Morelloflavone, a biflavonoid inhibitor of migration-related kinases, ameliorates atherosclerosis in mice Intestine-specific expression of Apobec-1 rescues apolipoprotein B RNA editing and alters chylomicron production in Apobec1 -/- mice.Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination.Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.Fortilin reduces apoptosis in macrophages and promotes atherosclerosis.Lipoproteins, cholesterol homeostasis and cardiac health.APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo.RNA binding to APOBEC deaminases; Not simply a substrate for C to U editing.Phylogenetic analysis of the apolipoprotein B mRNA-editing region. Evidence for a secondary structure between the mooring sequence and the 3' efficiency element.Re-editing the paradigm of Cytidine (C) to Uridine (U) RNA editing.Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice.Why does the gut choose apolipoprotein B48 but not B100 for chylomicron formation?When MicroRNAs Meet RNA Editing in Cancer: A Nucleotide Change Can Make a Difference.Epitranscriptomic profiling across cell types reveals associations between APOBEC1-mediated RNA editing, gene expression outcomes, and cellular function.

P2860

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P2860

Complete phenotypic characterization of apobec-1 knockout mice with a wild-type genetic background and a human apolipoprotein B transgenic background, and restoration of apolipoprotein B mRNA editing by somatic gene transfer of Apobec-1

Item

http://www.wikidata.org/entity/Q28291031

description

1996 nî lūn-bûn

@nan

1996 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

1996年の論文

@ja

1996年論文

@yue

1996年論文

@zh-hant

1996年論文

@zh-hk

1996年論文

@zh-mo

1996年論文

@zh-tw

1996年论文

@wuu