A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region
about
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation siteThe kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinaseDirect association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactionsRegulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylationCase report of novel DYRK1A mutations in 2 individuals with syndromic intellectual disability and a review of the literatureMouse models of Down syndrome as a tool to unravel the causes of mental disabilitiesThe structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteineCharacterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factorsDynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrateFunctional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndromeGene identification in 1.6-Mb region of the Down syndrome region on chromosome 21Identification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1ADyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in micePhosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A).Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.Role for YakA, cAMP, and protein kinase A in regulation of stress responses of Dictyostelium discoideum cellsRoles of the DYRK kinase Pom2 in cytokinesis, mitochondrial morphology, and sporulation in fission yeast.Phosphorylation by Dyrk1A of clathrin coated vesicle-associated proteins: identification of the substrate proteins and the effects of phosphorylation.DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors.Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammalsDyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome.Fruit flies and intellectual disability.NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effectLink between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndromeTransient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling.Physical and comparative mapping of distal mouse chromosome 16. 5 p5.Screening Dyrk1A inhibitors by MALDI-QqQ mass spectrometry: systematic comparison to established radiometric, luminescence, and LC-UV-MS assays.p53 downregulates Down syndrome-associated DYRK1A through miR-1246.Divergence of the genes on human chromosome 21 between human and other hominoids and variation of substitution rates among transcription unitsHuman neural stem cells: a new tool for studying cortical development in Down's syndrome.Trisomy 21 and early brain developmentTrisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndromeThe SR family proteins B52 and dASF/SF2 modulate development of the Drosophila visual system by regulating specific RNA targets.Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and IDTen new cases further delineate the syndromic intellectual disability phenotype caused by mutations in DYRK1A.Gene dosage-dependent association of DYRK1A with the cytoskeleton in the brain and lymphocytes of down syndrome patients.Brief Communication: Maternal Plasma Autoantibodies Screening in Fetal Down Syndrome.
P2860
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P2860
A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region
description
1996 nî lūn-bûn
@nan
1996 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
A human homologue of Drosophil ...... nd maps to the critical region
@ast
A human homologue of Drosophil ...... nd maps to the critical region
@en
A human homologue of Drosophil ...... nd maps to the critical region
@nl
type
label
A human homologue of Drosophil ...... nd maps to the critical region
@ast
A human homologue of Drosophil ...... nd maps to the critical region
@en
A human homologue of Drosophil ...... nd maps to the critical region
@nl
prefLabel
A human homologue of Drosophil ...... nd maps to the critical region
@ast
A human homologue of Drosophil ...... nd maps to the critical region
@en
A human homologue of Drosophil ...... nd maps to the critical region
@nl
P2093
P356
P1476
A human homologue of Drosophil ...... nd maps to the critical region
@en
P2093
A Domènech
A M Planas
C Pucharcòs
M A Pritchard
P304
P356
10.1093/HMG/5.9.1305
P407
P577
1996-09-01T00:00:00Z