Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives
about
Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroidsUDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patientsPolymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestineGastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylationStructure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferaseSubstrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33Molecular cloning, expression and characterization of a monkey steroid UDP-glucuronosyltransferase, UGT2B19, that conjugates testosterone.Isolation and characterization of the monkey UGT2B30 gene that encodes a uridine diphosphate-glucuronosyltransferase enzyme active on mineralocorticoid, glucocorticoid, androgen and oestrogen hormonesRegulated phosphorylation of a major UDP-glucuronosyltransferase isozyme by tyrosine kinases dictates endogenous substrate selection for detoxification.Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor.UGT genomic diversity: beyond gene duplication.Pharmacogenomics of human UDP-glucuronosyltransferase enzymes.Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient.Expression of UGT2B7, a UDP-glucuronosyltransferase implicated in the metabolism of 4-hydroxyestrone and all-trans retinoic acid, in normal human breast parenchyma and in invasive and in situ breast cancers.Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancerTranscriptional regulation of human UDP-glucuronosyltransferase genes.Meta-analysis of gene expression profiles identifies differential biomarkers for hepatocellular carcinoma and cholangiocarcinoma.Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation.Almokalant glucuronidation in human liver and kidney microsomes: evidence for the involvement of UGT1A9 and 2B7.The novel UGT1 gene complex links bilirubin, xenobiotics, and therapeutic drug metabolism by encoding UDP-glucuronosyltransferase isozymes with a common carboxyl terminus.Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides.
P2860
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P2860
Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives
description
1992 nî lūn-bûn
@nan
1992 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Two human liver cDNAs encode U ...... d certain estrogen derivatives
@ast
Two human liver cDNAs encode U ...... d certain estrogen derivatives
@en
Two human liver cDNAs encode U ...... d certain estrogen derivatives
@nl
type
label
Two human liver cDNAs encode U ...... d certain estrogen derivatives
@ast
Two human liver cDNAs encode U ...... d certain estrogen derivatives
@en
Two human liver cDNAs encode U ...... d certain estrogen derivatives
@nl
prefLabel
Two human liver cDNAs encode U ...... d certain estrogen derivatives
@ast
Two human liver cDNAs encode U ...... d certain estrogen derivatives
@en
Two human liver cDNAs encode U ...... d certain estrogen derivatives
@nl
P2093
P356
P1433
P1476
Two human liver cDNAs encode U ...... d certain estrogen derivatives
@en
P2093
P304
P356
10.1021/BI00128A015
P407
P577
1992-04-07T00:00:00Z