Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation
about
Integration of troponin I phosphorylation with cardiac regulatory networksPhosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin TWhy does troponin I have so many phosphorylation sites? Fact and fancyAblation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylationRemoval of the cardiac troponin I N-terminal extension improves cardiac function in aged mice.Reduced force production during low blood flow to the heart correlates with altered troponin I phosphorylationCardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy.Myofilament length dependent activationLeft ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.Top-down mass spectrometry of cardiac myofilament proteins in health and disease.10,000-fold concentration increase in proteins in a cascade microchip using anionic ITP by a 3-D numerical simulation with experimental results.Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade microchip by cationic isotachophoresisCeramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylationInterventricular differences in myofilament function in experimental congestive heart failure.Augmented phosphorylation of cardiac troponin I in hypertensive heart failure.10,000-fold concentration increase of the biomarker cardiac troponin I in a reducing union microfluidic chip using cationic isotachophoresis.Comprehensive analysis of protein modifications by top-down mass spectrometryIn vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated.Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model.Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathyContractile protein phosphorylation predicts human heart disease phenotypesExpression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytesMultiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins.Protein kinase Cepsilon: multiple roles in the function of, and signaling mediated by, the cytoskeleton.The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy.Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation.PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo.New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider?Thyroid hormone and cardiac repair/regeneration: from Prometheus myth to reality?Contribution of Post-translational Phosphorylation to Sarcomere-Linked Cardiomyopathy Phenotypes.PRKCE gene encoding protein kinase C-epsilon-Dual roles at sarcomeres and mitochondria in cardiomyocytes.The role of protein kinase C-mediated phosphorylation of sarcomeric proteins in the heart-detrimental or beneficial?Synergistic protection of MLC 1 against cardiac ischemia/reperfusion-induced degradation: a novel therapeutic concept for the future.Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice.Differential effects of phosphorylation of regions of troponin I in modifying cooperative activation of cardiac thin filaments.Protein kinase C contributes to the maintenance of contractile force in human ventricular cardiomyocytes.Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failureOxidative stress and heart failure in altered thyroid States
P2860
Q26852120-67F71925-5898-4078-B918-40961F13946BQ28239485-B0D3A182-FA10-4527-9150-F730FFB7FB3EQ28274412-9F5F8813-50F4-4216-8298-B5B62FCFF517Q28304945-0689B31D-B951-47BB-A203-76E28037D527Q30475106-D388DE24-D7DF-488B-B3B0-DC2F74C35161Q33641335-A21AA915-E7E7-4262-A9E5-C80508BFFF4DQ33782743-27D05F49-4413-467B-B038-1471158E4873Q33787650-11EAB468-AFCD-436E-963A-8995BC392BD5Q33822294-EE1998A9-6AC6-49B5-A6AC-0935183EE211Q34506950-609594B0-1030-466C-8560-A40981F3F0D1Q35588197-5BEC8980-02A2-43C4-B3E6-D18C6D402E2AQ35600289-FD8EA2C1-E441-4B4C-88C6-040698E5E2BEQ35634087-9677C10F-5081-4471-BFAF-88C5EFE6B9F8Q35636210-DA58B8E2-1E58-45B5-B355-3B72E05EB86FQ35668835-016F78A9-E5C4-4556-9D94-4A88F916A3B1Q35786165-B9AD5CC3-1A52-4A37-8FBC-E3F798D1CEFAQ35873932-5C9305E1-F06C-45B0-91C8-81F8027B623CQ35925687-48B6BF35-482A-4731-BF92-F5F601BC91CFQ36048967-4F378504-7012-4479-8855-5EC1221334F0Q36399795-2CFCBA65-E17C-4D13-9C37-310A4F200588Q36923928-2FB0AF54-1456-4B52-8AB2-EBD0322B06B7Q37086451-4681674E-2F58-45A0-9BA0-7E5E365C2F3AQ37196012-B076B4C0-C241-4B2D-B30F-5BF8BE42BC63Q37219740-D66078E4-3738-4950-9FC0-EE5247192C6DQ37239549-CE94C203-5235-4174-8627-5C49DD98199FQ37622081-41551B96-1BFA-4D86-AC70-BAC67A4BF5C0Q37671804-A2EEF52F-0072-4238-9B84-F847B7E79F6DQ37776431-EE4E25E4-158A-4899-A94D-AC4E6FA62091Q38023872-B84A03CA-C056-4D23-A9F5-F06B46DF1C2CQ38816583-E993D544-C384-4B40-9697-B46DE0F6F859Q38867832-511750AD-42C9-4853-93B5-1154E7F83CC6Q39310482-44089F2D-ABF7-4748-900D-050D9FC2CAA7Q39451153-64E6831A-CFA2-4D29-8E9F-058BD629FC28Q41248958-5A0358F7-39BC-4AE5-8852-989B84CBCC93Q42585795-DC38E6B5-2720-45A9-A593-2E016DC0AFD3Q46317401-C8DB3477-4CC2-435A-BA8F-3A4EF2C6D145Q57455682-DA16083B-6000-4771-9C32-9041B81CB515Q58915024-BA06639C-3FED-4C3E-87A2-431BEA9AE7F6
P2860
Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Partial replacement of cardiac ...... ith PKCepsilon phosphorylation
@ast
Partial replacement of cardiac ...... ith PKCepsilon phosphorylation
@en
Partial replacement of cardiac ...... ith PKCepsilon phosphorylation
@nl
type
label
Partial replacement of cardiac ...... ith PKCepsilon phosphorylation
@ast
Partial replacement of cardiac ...... ith PKCepsilon phosphorylation
@en
Partial replacement of cardiac ...... ith PKCepsilon phosphorylation
@nl
prefLabel
Partial replacement of cardiac ...... ith PKCepsilon phosphorylation
@ast
Partial replacement of cardiac ...... ith PKCepsilon phosphorylation
@en
Partial replacement of cardiac ...... ith PKCepsilon phosphorylation
@nl
P2093
P3181
P1476
Partial replacement of cardiac ...... ith PKCepsilon phosphorylation
@en
P2093
David L Geenen
Paul H Goldspink
Peter M Buttrick
R John Solaro
Sarah B Scruggs
Theodore Lyu
P304
P3181
P356
10.1016/J.YJMCC.2005.12.009
P407
P50
P577
2006-04-01T00:00:00Z