Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties

Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties

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http://www.wikidata.org/entity/Q28299013
The histamine H3 receptor: an attractive target for the treatment of cognitive disordersDetection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligandGlobal analysis of small molecule binding to related protein targetsEffects of the cognition-enhancing agent ABT-239 on fetal ethanol-induced deficits in dentate gyrus synaptic plasticityEffects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits.Histamine H3 receptor ligands break ground in a remarkable plethora of therapeutic areas.Preclinical evaluation of the abuse potential of Pitolisant, a histamine H₃ receptor inverse agonist/antagonist compared with ModafinilUse of the H3 receptor antagonist radioligand [3H]-A-349821 to reveal in vivo receptor occupancy of cognition enhancing H3 receptor antagonistsThe Histamine H3 Receptor: Structure, Pharmacology, and Function.Structure-based prediction of subtype selectivity of histamine H3 receptor selective antagonists in clinical trialsRecent advances in the development of histamine H3 antagonists.Histamine h3 receptor: a novel therapeutic target in alcohol dependence?H3 receptor antagonism enhances NCAM PSA-mediated plasticity and improves memory consolidation in odor discrimination and delayed match-to-position paradigms.Assessment of the abuse liability of ABT-288, a novel histamine H₃ receptor antagonist.
P2860

Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties

Item
http://www.wikidata.org/entity/Q28299013
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2005 nî lūn-bûn
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2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2005 թվականի ապրիլին հրատարակված գիտական հոդված
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