X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
about
IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradationRegulation of Cell Death by IAPs and Their AntagonistsSurvivin - The inconvenient IAPSmall-molecule SMAC mimetics as new cancer therapeuticsSurvivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasionDiscovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)IAP regulation of metastasis.E3 ligase activity of XIAP RING domain is required for XIAP-mediated cancer cell migration, but not for its RhoGDI binding activityHUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold.SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradationX-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton.LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signalingRhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility.Interaction of CSR1 with XIAP reverses inhibition of caspases and accelerates cell deathEffects of bevacizumab in mouse model of endometrial cancer: Defining the molecular basis for resistance.Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migrationIdentification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells.The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth.The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular StressRegulation of Apoptosis by Inhibitors of Apoptosis (IAPs)Small-molecule pan-IAP antagonists: a patent review.Chaperone-assisted degradation: multiple paths to destruction.Targeting inhibitor of apoptosis proteins for therapeutic intervention.Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets.Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration.Regulation of cell migration, invasion and metastasis by IAP proteins and their antagonists.IAPs on the move: role of inhibitors of apoptosis proteins in cell migration.AZD5582, an IAP antagonist that leads to apoptosis in head and neck squamous cell carcinoma cell lines and is eligible for combination with irradiation.Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer.Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins.XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling.Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization.Ubiquitin-mediated regulation of RhoGTPase signalling: IAPs and HACE1 enter the fray.The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoformsUbiquitin-dependent regulation of Cdc42 by XIAP.A novel function of cIAP1 as a mediator of CHIP-driven eIF4E regulation.IAPs as E3 ligases of Rac1: shaping the move.Smac Mimetic-Induced Upregulation of CCL2/MCP-1 Triggers Migration and Invasion of Glioblastoma Cells and Influences the Tumor Microenvironment in a Paracrine Manner.X-linked inhibitor of apoptosis protein negatively regulates neuronal differentiation through interaction with cRAF and Trk.Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade.
P2860
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P2860
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
@ast
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
@en
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
@nl
type
label
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
@ast
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
@en
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
@nl
prefLabel
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
@ast
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
@en
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
@nl
P2093
P2860
P356
P1433
P1476
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
@en
P2093
Christiaan Karreman
Emad S Alnemri
Gregory S Harms
Krishnaraj Rajalingam
Mirko Hekman
Taner Dogan
Tripat Kaur Oberoi
Ulf R Rapp
P2860
P2888
P304
P356
10.1038/NCB1804
P407
P577
2008-12-01T00:00:00Z
P5875
P6179
1017925206