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Origin of primate orphan genes: a comparative genomics approach

Origin of primate orphan genes: a comparative genomics approach

http://www.wikidata.org/entity/Q28303276

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NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas The life cycle of Drosophila orphan genes De novo ORFs in Drosophila are important to organismal fitness and evolved rapidly from previously non-coding sequences Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa De novo origins of human genes Darwinian alchemy: Human genes from noncoding DNA Recent de novo origin of human protein-coding genes In silico prediction of physical protein interactions and characterization of interactome orphans Disruption of RAB40AL function leads to Martin--Probst syndrome, a rare X-linked multisystem neurodevelopmental human disorder On the evolutionary relationship between chondrocytes and osteoblasts New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation CHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury Genes from scratch--the evolutionary fate of de novo genes Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates Structural View of a Non Pfam Singleton and Crystal Packing Analysis Mechanisms and dynamics of orphan gene emergence in insect genomes Interaction-based evolution: how natural selection and nonrandom mutation work together Genome-wide identification, characterization, and expression analysis of lineage-specific genes within zebrafish PBOV1 is a human de novo gene with tumor-specific expression that is associated with a positive clinical outcome of cancer Why so many unknown genes? Partitioning orphans from a representative transcriptome of the lone star tick Amblyomma americanum De novo origin of protein-coding genes in murine rodents In with the old, in with the new: the promiscuity of the duplication process engenders diverse pathways for novel gene creation The Recent De Novo Origin of Protein C-Termini.Transposable Elements and DNA Methylation Create in Embryonic Stem Cells Human-Specific Regulatory Sequences Associated with Distal Enhancers and Noncoding RNAs Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx.The other side of comparative genomics: genes with no orthologs between the cow and other mammalian species.A human-specific de novo protein-coding gene associated with human brain functions.Bioinformatics Analysis of the FREM1 Gene-Evolutionary Development of the IL-1R1 Co-Receptor, TILRR.No Evidence for Phylostratigraphic Bias Impacting Inferences on Patterns of Gene Emergence and Evolution.Functions of alternative replication protein A in initiation and elongation Similarly strong purifying selection acts on human disease genes of all evolutionary ages.The evolution of human cells in terms of protein innovation.Evolutionary origins of Brassicaceae specific genes in Arabidopsis thaliana.Origins, evolution, and phenotypic impact of new genes.Young proteins experience more variable selection pressures than old proteins.Evolution of viral proteins originated de novo by overprinting Phylogenetic patterns of emergence of new genes support a model of frequent de novo evolution.Relaxed purifying selection and possibly high rate of adaptation in primate lineage-specific genes The influence of rickettsiologists on post-modern microbiology.Hominoid-specific de novo protein-coding genes originating from long non-coding RNAs.

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Origin of primate orphan genes: a comparative genomics approach

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2009 nî lūn-bûn

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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Origin of primate orphan genes: a comparative genomics approach

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Origin of primate orphan genes: a comparative genomics approach

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Origin of primate orphan genes: a comparative genomics approach

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Origin of primate orphan genes: a comparative genomics approach

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Origin of primate orphan genes: a comparative genomics approach

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Origin of primate orphan genes: a comparative genomics approach

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Origin of primate orphan genes: a comparative genomics approach

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Origin of primate orphan genes: a comparative genomics approach

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Origin of primate orphan genes: a comparative genomics approach

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Molecular Biology and Evolution

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Origin of primate orphan genes: a comparative genomics approach

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Lluis Armengol

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M Mar Albà

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Nicolás Bellora

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Nina Bosch

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Robert Castelo

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P2860

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

Lineage-specific gene duplication and loss in human and great ape evolution

Birth of a unique enzyme from an alternative reading frame of the preexisted, internally repetitious coding sequence

Initial sequencing and comparative analysis of the mouse genome

De novo origination of a new protein-coding gene in Saccharomyces cerevisiae

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Irreversible repression of DNA synthesis in Fanconi anemia cells is alleviated by the product of a novel cyclin-related gene

TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

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10.1093/MOLBEV/MSN281

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3

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26

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Macarena Toll-Riera

Xavier Estivill i Pallejà

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23640061

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19064677

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