Posttranslational modification of proteins by isoprenoids in mammalian cells
about
Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylatedLovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductaseMutational analysis of delta antigen: effect on assembly and replication of hepatitis delta virusMolecular Analysis of the Prostacyclin Receptor’s Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1Crystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug designProtein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene productSubcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity.Farnesol is utilized for isoprenoid biosynthesis in plant cells via farnesyl pyrophosphate formed by successive monophosphorylation reactionsPravastatin suppresses the interleukin-8 production induced by thrombin in human aortic endothelial cells cultured with high glucose by inhibiting the p44/42 mitogen activated protein kinaseThe effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP-receptorIdentification of a farnesol analog as a Ras function inhibitor using both an in vivo Ras activation sensor and a phenotypic screening approach.Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumoursNovel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statinsSterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene.Structural analysis of protein prenyl groups and associated C-terminal modificationsEffects of statins on the risk of hepatocellular carcinomaEffect of the statin atorvastatin on intracellular signalling by the prostacyclin receptor in vitro and in vivo.Signals for the induction of nitric oxide synthase in astrocytes.Lipid-lowering drugs.Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.Oocyte activation and passage through the metaphase/anaphase transition of the meiotic cell cycle is blocked in clams by inhibitors of HMG-CoA reductase activity.Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene.In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure.Synthetic isoprenoid analogues for the study of prenylated proteins: Fluorescent imaging and proteomic applications.Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences.Lipopolysaccharide-induced NF-kappa B activation in mouse 70Z/3 pre-B lymphocytes is inhibited by mevinolin and 5'-methylthioadenosine: roles of protein isoprenylation and carboxyl methylation reactions.Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear laminaA microsomal endoprotease that specifically cleaves isoprenylated peptidesFarnesylcysteine, a constituent of the alpha and beta subunits of rabbit skeletal muscle phosphorylase kinase: localization by conversion to S-ethylcysteine and by tandem mass spectrometryStatins inhibit the growth of variant human embryonic stem cells and cancer cells in vitro but not normal human embryonic stem cells.A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acidQuantitative assay for morphogenesis indicates the role of extracellular matrix components and G proteins.Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells.Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity.Ubiquitin-RAS peptide extensions as substrates for farnesyl-protein transferase and carboxymethyltransferase.A prenylation inhibitor prevents production of infectious hepatitis delta virus particlesIn vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis
P2860
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P2860
Posttranslational modification of proteins by isoprenoids in mammalian cells
description
1990 nî lūn-bûn
@nan
1990 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Posttranslational modification of proteins by isoprenoids in mammalian cells
@ast
Posttranslational modification of proteins by isoprenoids in mammalian cells
@en
Posttranslational modification of proteins by isoprenoids in mammalian cells
@nl
type
label
Posttranslational modification of proteins by isoprenoids in mammalian cells
@ast
Posttranslational modification of proteins by isoprenoids in mammalian cells
@en
Posttranslational modification of proteins by isoprenoids in mammalian cells
@nl
prefLabel
Posttranslational modification of proteins by isoprenoids in mammalian cells
@ast
Posttranslational modification of proteins by isoprenoids in mammalian cells
@en
Posttranslational modification of proteins by isoprenoids in mammalian cells
@nl
P1433
P1476
Posttranslational modification of proteins by isoprenoids in mammalian cells
@en
P2093
W A Maltese
P304
P407
P577
1990-12-01T00:00:00Z