Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility - Wikidata - wikimedia - TriplyDB

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

http://www.wikidata.org/entity/Q28304661

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Regulation of TAZ in cancer A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.Time and Circumstances: Cancer Cell Metabolism at Various Stages of Disease Progression Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy CD44, Hyaluronan, the Hematopoietic Stem Cell, and Leukemia-Initiating Cells Hippo/YAP pathway for targeted therapy Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.Mammalian Eps15 homology domain 1 promotes metastasis in non-small cell lung cancer by inducing epithelial-mesenchymal transition.Transforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion Identification, design and synthesis of tubulin-derived peptides as novel hyaluronan mimetic ligands for the receptor for hyaluronan-mediated motility (RHAMM/HMMR).Aerobic glycolysis tunes YAP/TAZ transcriptional activity Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy Simvastatin alleviates cardiac fibrosis induced by infarction via up-regulation of TGF-β receptor III expression.The emerging roles of YAP and TAZ in cancer RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3.Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells.Up-regulation of miR-506 inhibits cell growth and disrupt the cell cycle by targeting YAP in breast cancer cells.The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1.A novel HMGA1-CCNE2-YAP axis regulates breast cancer aggressiveness.Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells.Inactivation of hypoxia-induced YAP by statins overcomes hypoxic resistance tosorafenib in hepatocellular carcinoma cells.The Hippo pathway, p53 and cholesterol miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer.HMG-CoAR expression in male breast cancer: relationship with hormone receptors, Hippo transducers and survival outcomes.CYR61 (CCN1) is a metastatic biomarker of gastric cardia adenocarcinoma.Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis.Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in non-small cell lung carcinoma.Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells.YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins.Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis.Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer.The Hippo signaling pathway provides novel anti-cancer drug targets.Role of receptor for hyaluronan-mediated motility (RHAMM) in human head and neck cancers.The Hippo signal transduction network in skeletal and cardiac muscle.Hyaluronan and RHAMM in wound repair and the "cancerization" of stromal tissues.

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P2860

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

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Fang Zhang

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Haifeng Wang

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Hongbo Chen

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Laiqiang Huang

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Lin Mei

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Na Li

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Shengnan Sun

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Xudong Zhang

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Xuexun Fang

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Yangqing Zhang

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P2860

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells

The hippo signaling pathway in development and cancer

Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

Expression of the hyaluronan receptor RHAMM in endometrial carcinomas suggests a role in tumour progression and metastasis

Hyaluronate receptors mediating glioma cell migration and proliferation

How does a protein with dual mitotic spindle and extracellular matrix receptor functions affect tumor susceptibility and progression?

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