In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations - Wikidata - wikimedia - TriplyDB

In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations

In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations

http://www.wikidata.org/entity/Q28305805

about

A mouse model of juvenile hemochromatosis.Hereditary hemochromatosis in the post-HFE era The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease SLC40A1 Q248H allele frequencies and Q248H-associated risk of non-HFE iron overload in persons of sub-Saharan African descent Ironing out Ferroportin Investigation of the biophysical and cell biological properties of ferroportin, a multipass integral membrane protein iron exporter.Human macrophage ferroportin biology and the basis for the ferroportin disease.Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc.Human mutation D157G in ferroportin leads to hepcidin-independent binding of Jak2 and ferroportin down-regulation.Pathophysiological consequences and benefits of HFE mutations: 20 years of research.The molecular basis of ferroportin-linked hemochromatosis.Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating plasma tumor necrosis factor-alpha and macrophage migration inhibitory factor concentrations in African children.Ferroportin disease: a systematic meta-analysis of clinical and molecular findings.Non-HFE hemochromatosis Hemizygous deletion of COL3A1, COL5A2, and MSTN causes a complex phenotype with aortic dissection: a lesson for and from true haploinsufficiency Novel gain of function mutation in the SLC40A1 gene associated with hereditary haemochromatosis type 4.EMQN best practice guidelines for the molecular genetic diagnosis of hereditary hemochromatosis (HH).Hepcidin induces HIV-1 transcription inhibited by ferroportin Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin.Hepcidin--central regulator of iron metabolism.Iron imports. III. Transfer of iron from the mucosa into circulation.Evidence for the multimeric structure of ferroportin.Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.The molecular mechanism of hepcidin-mediated ferroportin down-regulation.Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption.Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations.Liver iron transport The molecular genetics of haemochromatosis.Iron overload due to mutations in ferroportin.Lipocalin-2 ensures host defense against Salmonella Typhimurium by controlling macrophage iron homeostasis and immune response The ins and outs of iron homeostasis.Forging a field: the golden age of iron biology.Role of cellular iron and oxygen in the regulation of HIV-1 infection.Clinical, pathological, and molecular correlates in ferroportin disease: a study of two novel mutations.Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.The molecular basis of hepcidin-resistant hereditary hemochromatosis.Regulation of iron absorption in hemoglobinopathies.The Regulation of Iron Absorption and Homeostasis.Zebrafish in the sea of mineral (iron, zinc, and copper) metabolism.

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P2860

In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations

http://www.wikidata.org/entity/Q28305805

description

2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

In vitro functional analysis o ...... tosis-associated FPN mutations

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In vitro functional analysis o ...... tosis-associated FPN mutations

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In vitro functional analysis o ...... tosis-associated FPN mutations

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type

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In vitro functional analysis o ...... tosis-associated FPN mutations

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In vitro functional analysis o ...... tosis-associated FPN mutations

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In vitro functional analysis o ...... tosis-associated FPN mutations

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In vitro functional analysis o ...... tosis-associated FPN mutations

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In vitro functional analysis o ...... tosis-associated FPN mutations

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In vitro functional analysis o ...... tosis-associated FPN mutations

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Alison T Merryweather-Clarke

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Diana Cowley

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Emma Sweetland

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Hal Drakesmith

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Alain R.M. Townsend

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8040745

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