Cyclin-dependent kinase pathways as targets for cancer treatment
about
The anti-melanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signalingAn overview of Cdk1-controlled targets and processesA first-in-human, phase 1, dose-escalation study of dinaciclib, a novel cyclin-dependent kinase inhibitor, administered weekly in subjects with advanced malignanciesThe structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylationCyclin-dependent kinase inhibitor therapy for hematologic malignanciesMaintaining Genome Stability in Defiance of Mitotic DNA DamagePalbociclib - from Bench to Bedside and BeyondTetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapyThe emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancerTargeted Therapies in Adult B-Cell MalignanciesTargeting CDK6 in cancer: State of the art and new insightsTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsCDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma CellsSubstituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer ActivitiesFragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 InhibitorsTherapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure.Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancersCombined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1Cyclin D as a therapeutic target in cancerCyclin-dependent kinases 4 and 6 control tumor progression and direct glucose oxidation in the pentose cyclePurvalanol A, olomoucine II and roscovitine inhibit ABCB1 transporter and synergistically potentiate cytotoxic effects of daunorubicin in vitroFatty acid esters of phloridzin induce apoptosis of human liver cancer cells through altered gene expressionVMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells.Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell deathEnhancing circadian clock function in cancer cells inhibits tumor growthAn integrative in silico approach for discovering candidates for drug-targetable protein-protein interactions in interactome dataInhibitory effect of schisandrin B on gastric cancer cells in vitroTargeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263.Phase I trial of bortezomib (PS-341; NSC 681239) and "nonhybrid" (bolus) infusion schedule of alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory indolent B-cell neoplasms.A Phase I Study of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib (LEE011) in Patients with Advanced Solid Tumors and LymphomasPalbociclib: A breakthrough in breast carcinoma in women.Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastropheRole of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death.Recent advances of highly selective CDK4/6 inhibitors in breast cancerEmerging therapies for breast cancerChemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032Molecular and cellular effects of multi-targeted cyclin-dependent kinase inhibition in myeloma: biological and clinical implications.Novel Strategies to Improve the Endocrine Therapy of Breast Cancer.Association between p16(CDKN2A) C540G polymorphism and tumor behavior in prolactinoma: A single-center studyCDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner.
P2860
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P2860
Cyclin-dependent kinase pathways as targets for cancer treatment
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Cyclin-dependent kinase pathways as targets for cancer treatment
@ast
Cyclin-dependent kinase pathways as targets for cancer treatment
@en
Cyclin-dependent kinase pathways as targets for cancer treatment
@nl
type
label
Cyclin-dependent kinase pathways as targets for cancer treatment
@ast
Cyclin-dependent kinase pathways as targets for cancer treatment
@en
Cyclin-dependent kinase pathways as targets for cancer treatment
@nl
prefLabel
Cyclin-dependent kinase pathways as targets for cancer treatment
@ast
Cyclin-dependent kinase pathways as targets for cancer treatment
@en
Cyclin-dependent kinase pathways as targets for cancer treatment
@nl
P3181
P356
P1476
Cyclin-dependent kinase pathways as targets for cancer treatment
@en
P2093
Geoffrey I Shapiro
P304
P3181
P356
10.1200/JCO.2005.03.7689
P407
P577
2006-04-10T00:00:00Z