Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ
about
PHD2: from hypoxia regulation to disease progressionHIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasisBAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters.Evolutionary selected Tibetan variants of HIF pathway and risk of lung cancer.Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model.Molecular oxygen sensing: implications for visceral surgery.HIF-prolyl hydroxylases and cardiovascular diseases.Hypoxia-inducible factors as key regulators of tumor inflammation.Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force.Prolyl 4-hydroxylases, master regulators of the hypoxia response.Genetic modification of hypoxia signaling in animal models and its effect on cancer.PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages.Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor growth in mammary gland carcinoma.PHD1 regulates p53-mediated colorectal cancer chemoresistance.PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner.Nucleotropic doxorubicin nanoparticles decrease cancer cell viability, destroy mitochondria, induce autophagy and enhance tumour necrosis.New Insights into Protein Hydroxylation and Its Important Role in Human Diseases.Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-αTherapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges.Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development.HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFβ activation.Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling.Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C.Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-β1 processing.Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment.Hypoxic Signalling in Tumour Stroma.
P2860
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P2860
Inhibition of HIF prolyl hydroxylase-2 blocks tumor growth in mice through the antiproliferative activity of TGFβ
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Inhibition of HIF prolyl hydro ...... proliferative activity of TGFβ
@ast
Inhibition of HIF prolyl hydro ...... proliferative activity of TGFβ
@en
Inhibition of HIF prolyl hydro ...... proliferative activity of TGFβ
@nl
type
label
Inhibition of HIF prolyl hydro ...... proliferative activity of TGFβ
@ast
Inhibition of HIF prolyl hydro ...... proliferative activity of TGFβ
@en
Inhibition of HIF prolyl hydro ...... proliferative activity of TGFβ
@nl
prefLabel
Inhibition of HIF prolyl hydro ...... proliferative activity of TGFβ
@ast
Inhibition of HIF prolyl hydro ...... proliferative activity of TGFβ
@en
Inhibition of HIF prolyl hydro ...... proliferative activity of TGFβ
@nl
P2093
P50
P3181
P1433
P1476
Inhibition of HIF prolyl hydro ...... proliferative activity of TGFβ
@en
P2093
Anne Klotzsche-von Ameln
Antje Muschter
David M Poitz
Kristin Franke
Maryam Rezaei
Soulafa Mamlouk
P304
P3181
P356
10.1158/0008-5472.CAN-10-3838
P407
P577
2011-03-24T00:00:00Z