about
AIPL1, a protein implicated in Leber's congenital amaurosis, interacts with and aids in processing of farnesylated proteinsMutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type MaroteauxNO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism.Tazobactam forms a stoichiometric trans-enamine intermediate in the E166A variant of SHV-1 beta-lactamase: 1.63 A crystal structureCrystal Structure of KPC-2: Insights into Carbapenemase Activity in Class A β-Lactamases † , ‡PAS-mediated Dimerization of Soluble Guanylyl Cyclase Revealed by Signal Transduction Histidine Kinase Domain Crystal StructureStrategic Design of an Effective -Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONECrystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclaseStructure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.Design, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 CarbapenemaseNovel Insights into the Mode of Inhibition of Class A SHV-1 -Lactamases Revealed by Boronic Acid Transition State InhibitorsLigand-Dependent Disorder of the Loop Observed in Extended-Spectrum SHV-Type -LactamaseCrystal Structure of a Preacylation Complex of the β-Lactamase Inhibitor Sulbactam Bound to a Sulfenamide Bond-Containing Thiol-β-lactamaseStructures of SHV-1 β-Lactamase with Penem and Penam Sulfone Inhibitors That Form Cyclic Intermediates Stabilized by Carbonyl ConjugationDesign and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with a Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-LactamaseCrystal Structures of KPC-2 -Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226Insights into BAY 60-2770 Activation and S -Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain ComplexesThe Importance of thetrans-Enamine Intermediate as a β-Lactamase Inhibition Strategy Probed in Inhibitor-Resistant SHV β-Lactamase Variantsβ-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-EnzymeStructure of an Engineered β-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric RegulationPenam Sulfones and β-Lactamase Inhibition: SA2-13 and the Importance of the C2 Side Chain Length and Composition
P50
Q24297621-A41EA8B2-F10B-4BBB-A3AE-06F73535D2F3Q24533528-D36286DA-6262-4F1A-9748-63CBB4AFF66DQ27641107-720A8067-2458-4ADA-98C4-99E9BBA9C749Q27643027-05B09802-6F6C-42CD-962E-B8F218110924Q27644490-B4AA899A-4CE2-407C-9A76-7D49BA4E8C2DQ27649070-971D9FFB-A253-481C-94D2-7B0D16DCFA38Q27652684-9ACB12B3-83E6-4F2C-B4B1-1F62602581B5Q27659219-045D79C8-2580-4C24-960F-2CDFA947AF0CQ27661554-9030976F-4F04-478A-827C-9067FC8542CEQ27664292-0FD89C91-F77E-4B22-A7F1-CBBBE2BF94EBQ27665516-A32BC1B9-651B-4C70-9894-C694A5BF110DQ27667091-79752317-1F65-4331-A6E7-0D12507489BAQ27673054-93FB9A57-3E72-4BA5-B5DC-79EB19D313C5Q27675092-B8B6313F-7DC5-4585-86C1-7027FCFBABD8Q27675536-AA496231-E44A-4453-AC40-0CC23A7C9036Q27677247-69BFD540-CDFE-4A57-91E2-6FC25A32FE0CQ27677544-E69A756D-99FF-4909-8AD0-06922923EE9BQ27678147-86B1D098-BB61-487E-9CC5-404CF1E9DE41Q27680584-01F5738A-4D08-4CE8-B2DF-3F66BC5B72F0Q27681287-4DE4E367-A70A-4FCE-A495-66BEBCBF86DAQ27681435-B3DEF1EB-5FDB-48B7-A1DA-B8496F72BCB2
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Focco van den Akker
@ast
Focco van den Akker
@en
Focco van den Akker
@es
Focco van den Akker
@nl
Focco van den Akker
@sl
type
label
Focco van den Akker
@ast
Focco van den Akker
@en
Focco van den Akker
@es
Focco van den Akker
@nl
Focco van den Akker
@sl
prefLabel
Focco van den Akker
@ast
Focco van den Akker
@en
Focco van den Akker
@es
Focco van den Akker
@nl
Focco van den Akker
@sl