about
Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductaseX-ray-induced deterioration of disulfide bridges at atomic resolutionNeutron structure of type-III antifreeze protein allows the reconstruction of AFP-ice interfaceCrystal packing modifies ligand binding affinity: The case of aldose reductaseStructural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchangerX-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivityFrataxin from Psychromonas ingrahamii as a model to study stability modulation within the CyaY protein family2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitorsDiscovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injuryLinear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reactionIdentification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug designStructural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10Structural characterization of metal binding to a cold-adapted frataxinThe Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase InhibitionNew insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MMStructural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferaseIDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Alexandra Cousido-Siah
@ast
Alexandra Cousido-Siah
@en
Alexandra Cousido-Siah
@es
Alexandra Cousido-Siah
@nl
Alexandra Cousido-Siah
@sl
type
label
Alexandra Cousido-Siah
@ast
Alexandra Cousido-Siah
@en
Alexandra Cousido-Siah
@es
Alexandra Cousido-Siah
@nl
Alexandra Cousido-Siah
@sl
prefLabel
Alexandra Cousido-Siah
@ast
Alexandra Cousido-Siah
@en
Alexandra Cousido-Siah
@es
Alexandra Cousido-Siah
@nl
Alexandra Cousido-Siah
@sl