about
Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screeningProtein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthaseThe structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolismInhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic DrugsX-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitorsVirtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activityStructure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors.2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes.Optimization of peptides that target human thymidylate synthase to inhibit ovarian cancer cell growth.Ligand-based virtual screening and ADME-tox guided approach to identify triazolo-quinoxalines as folate cycle inhibitors.Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells.
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Rosaria Luciani
@ast
Rosaria Luciani
@en
Rosaria Luciani
@es
Rosaria Luciani
@fr
Rosaria Luciani
@nl
Rosaria Luciani
@sl
type
label
Rosaria Luciani
@ast
Rosaria Luciani
@en
Rosaria Luciani
@es
Rosaria Luciani
@fr
Rosaria Luciani
@nl
Rosaria Luciani
@sl
prefLabel
Rosaria Luciani
@ast
Rosaria Luciani
@en
Rosaria Luciani
@es
Rosaria Luciani
@fr
Rosaria Luciani
@nl
Rosaria Luciani
@sl
P1053
D-9148-2015
P106
P21
P31
P3829
P496
0000-0003-1367-0217
P569
2000-01-01T00:00:00Z