Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct
about
Degradation of cytochrome P-450 haem by carbon tetrachloride and 2-allyl-2-isopropylacetamide in rat liver in vivo and in vitro. Involvement of non-carbon monoxide-forming mechanismsFractionation and purification of hepatic microsomal cytochrome P-450 isoenzymes from phenobarbital-pretreated rats by h.p.l.c. A convenient tool for screening of isoenzymes inactivated by allylisopropylacetamideThe effect of fluroxene [(2,2,2-trifluoroethoxy)ethane] on haem biosynthesis and degradationDefective utilization of haem in selenium-deficient rat liverMetabolism of hepatic haem and 'green pigments' in rats given 2-allyl-2-isopropylacetamide and ferric citrate. A new model for hepatic haem turnoverHaem control in experimental porphyria. The effect of haemin on the induction of delta-aminolaevulinate synthase in isolated chick-embryo liver cellsInhibition of protohaem ferro-lyase by N-substituted porphyrins. Structural requirements for the inhibitory effectInactivation of cytochrome P-450 and production of N-alkylated porphyrins caused in isolated hepatocytes by substituted dihydropyridines. Structural requirements for loss of haem and alkylation of the pyrrole nitrogen atom.Drug-induced conversion of liver haem into modified porphyrins. Evidence for two classes of products.Inhibition of protohaem ferro-lyase in experimental porphyria. Isolation and partial characterization of a modified porphyrin inhibitor.Conversion of liver haem into N-substituted porphyrins or green pigments. Nature of the substituent at the pyrrole nitrogen atom.Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal.N-Methylprotoporphyrin IX: chemical synthesis and identification as the green pigment produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine treatmentSelf-catalyzed destruction of cytochrome P-450: covalent binding of ethynyl sterols to prosthetic heme.Exposure to toxic agents: the heme biosynthetic pathway and hemoproteins as indicator.Inhibitors of Cytochrome P-450s and their mechanism of action.Degradation of endogenous hepatic heme by pathways not yielding carbon monoxide. Studies in normal rat liver and in primary hepatocyte culture.Alteration of the porphyrin nucleus of cytochrome P-450 caused in the liver by treatment with allyl-containing drugs. Is the modified porphyrin N-substituted?Patterns of porphyrin accumulation in response to xenobiotics. Parallels between results in chick embryo and rodents.
P2860
Q28319324-319F2634-6AC1-4941-A9F6-CBA476FEC6E4Q28362226-390EAFEE-5854-4E2B-B79C-A93BE0022409Q28365727-539443FB-69CC-4F66-AAE4-69A3C475A20AQ28366924-F137A2A9-1FC6-4C84-96EB-BD10FECFBAC2Q28367154-4D96145D-E408-4AE0-8FB0-6C08BCF0270DQ28367339-0C842DFD-555B-42FB-9C70-3319553BA97BQ28368000-4EFF4F66-178B-4895-950A-1A45E9EF46E5Q33391156-0BFE12C6-6903-475D-ADC2-190F6E71BCE8Q33391225-5C949A8C-F909-4412-8E56-8056EA7F1527Q33391228-3105A41A-3654-45D5-86CC-6FE260C6E08DQ33391232-CF75BD9C-7BE4-4D9B-B10F-F5C7C5640C15Q34555359-471B18AD-03D3-4AB9-8578-C16A64F653C6Q35321939-1B80EDBB-1EA0-49BC-9527-545015B33DBCQ37314759-D77C82FB-D28C-4DA0-84EF-59F1E7815663Q39829778-7BC343B3-EC86-4355-AD3B-23108458D053Q40317968-8EBEF5FB-9F77-47F1-A056-12573C7A9A84Q40686899-F5893295-7205-4EF1-8484-8273E0940F94Q41836243-71798A67-57EC-444B-82EF-186705BBE94DQ42208747-4EC3451F-4B91-4AF0-A3EB-3C71693A18CA
P2860
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct
description
1978 nî lūn-bûn
@nan
1978 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1978 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1978年の論文
@ja
1978年論文
@yue
1978年論文
@zh-hant
1978年論文
@zh-hk
1978年論文
@zh-mo
1978年論文
@zh-tw
1978年论文
@wuu
name
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct
@ast
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct
@en
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct
@nl
type
label
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct
@ast
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct
@en
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct
@nl
prefLabel
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct
@ast
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct
@en
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct
@nl
P2093
P921
P1476
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct
@en
P2093
P R Ortiz de Montellano
P356
10.1016/0006-291X(78)90407-2
P407
P577
1978-07-14T00:00:00Z