4-amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brain
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Experimental studies of the influence of vigabatrin on the GABA systemStructures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrinReward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviorsGamma-vinyl GABA, an irreversible inhibitor of GABA transaminase, alters the acquisition and expression of cocaine-induced sensitization in male ratsThe Concise Guide to PHARMACOLOGY 2013/14: enzymes.The potential for vigabatrin-induced intramyelinic edema in humans.Effect of vigabatrin on striatal dopamine receptors: evidence in humans for interactions of GABA and dopamine systems.The pharmacologic basis of antiepileptic drug action.Vigabatrin: a novel therapy for seizure disorders.Placental transfer of vigabatrin (gamma-vinyl GABA) and its effect on concentration of amino acids in the embryo of TO mice.Chronic toxicity studies with vigabatrin, a GABA-transaminase inhibitor.The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile sLocalized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.Antiepileptic drug mechanisms of action.Inhibition of the enzyme, GABA-aminotransferase in human platelets by vigabatrin, a potential antiepileptic drug.Monitoring vigabatrin in head injury patients by cerebral microdialysis: obtaining pharmacokinetic measurements in a neurocritical care setting.Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations.Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115)Design and mechanism of tetrahydrothiophene-based γ-aminobutyric acid aminotransferase inactivators.(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.Antiepileptic drugs in neuroprotection.Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferaseSynthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase.(+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathwayFluorinated conformationally restricted gamma-aminobutyric acid aminotransferase inhibitorsVigabatrin: a comprehensive review of drug properties including clinical updates following recent FDA approval.Vigabatrin for infantile spasms.Ornithine aminotransferase versus GABA aminotransferase: implications for the design of new anticancer drugs.Pharmacokinetic aspects of the anti-epileptic drug substance vigabatrin: focus on transporter interactions.Clinical pharmacology of vigabatrinThe potential use of mechanism-based enzyme inactivators in medicine.An historical perspective on GABAergic drugs.Clavulanic acid does not affect convulsions in acute seizure tests in mice.alpha-difluoromethyl DOPA, a new enzyme-activated irreversible inhibitor of aromatic L-amino acid decarboxylase.Identification and preclinical testing of novel antiepileptic compounds.Pharmacokinetic profile of topiramate in comparison with other new antiepileptic drugs.Update on the mechanism of action of antiepileptic drugs.Enzyme-induced inactivation of transminases by acetylenic and vinyl analogues of 4-aminobutyrate.gamma-Vinyl GABA: effects of chronic administration on the metabolism of GABA and other amino compounds in rat brain.Effects of ethanolamine-O-sulphate and gamma-acetylenic-GABA on GABA content, GAD and GABA-T in various areas of chick brain after intraventricular microinjection.
P2860
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P2860
4-amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brain
description
1977 nî lūn-bûn
@nan
1977 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1977 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1977年の論文
@ja
1977年論文
@yue
1977年論文
@zh-hant
1977年論文
@zh-hk
1977年論文
@zh-mo
1977年論文
@zh-tw
1977年论文
@wuu
name
4-amino-hex-5-enoic acid, a se ...... transferase in mammalian brain
@ast
4-amino-hex-5-enoic acid, a se ...... transferase in mammalian brain
@en
4-amino-hex-5-enoic acid, a se ...... transferase in mammalian brain
@nl
type
label
4-amino-hex-5-enoic acid, a se ...... transferase in mammalian brain
@ast
4-amino-hex-5-enoic acid, a se ...... transferase in mammalian brain
@en
4-amino-hex-5-enoic acid, a se ...... transferase in mammalian brain
@nl
prefLabel
4-amino-hex-5-enoic acid, a se ...... transferase in mammalian brain
@ast
4-amino-hex-5-enoic acid, a se ...... transferase in mammalian brain
@en
4-amino-hex-5-enoic acid, a se ...... transferase in mammalian brain
@nl
P2093
P1433
P1476
4-amino-hex-5-enoic acid, a se ...... transferase in mammalian brain
@en
P2093
P356
10.1111/J.1432-1033.1977.TB11410.X
P407
P577
1977-04-15T00:00:00Z