A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)
about
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcri[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptaseSynergistic inhibition of human immunodeficiency virus type 1 replication by 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil (E-EPU) and azidothymidine in vitroBisheteroarylpiperazine reverse transcriptase inhibitor in combination with 3'-azido-3'-deoxythymidine or 2',3'-dideoxycytidine synergistically inhibits human immunodeficiency virus type 1 replication in vitroDifferential activities of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives against different human immunodeficiency virus type 1 mutant strainsHuman immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analoStructure-based design of novel dihydroalkoxybenzyloxopyrimidine derivatives as potent nonnucleoside inhibitors of the human immunodeficiency virus reverse transcriptaseStructure-based design of non-nucleoside reverse transcriptase inhibitors of drug-resistant human immunodeficiency virus3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integraseN-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and IntegraseAntiretroviral therapy: reverse transcriptase inhibition.Synthesis and antiviral screening of some thieno[2,3-d]pyrimidine nucleosides.6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.Comparative study of non nucleoside inhibitors with HIV-1 reverse transcriptase based on 3D-QSAR and docking.Design of novel leads: ligand based computational modeling studies on non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1.Structure-activity relationship studies on potential non-nucleoside DABO-like inhibitors of HIV-1 reverse transcriptase.The synthesis of novel 6,5- and 6,6-membered fused heterocyclic compounds derived from thymine.Efficient synthesis of fused isothiazolo C-nucleosides. III. Synthesis of substituted isothiazol.QSAR for anti-HIV activity of HEPT derivatives.4D-QSAR study of HEPT derivatives by electron conformational-genetic algorithm method.
P2860
Q28316183-6E60F81F-E18A-4ECB-8DD5-746DAE987C7EQ28318473-AD7C90E3-C280-422F-9225-8F64C7C2137DQ28323740-037356AE-8FD1-40B3-9808-43D64A29D0C1Q28333682-80D6A89F-6A54-46A1-869B-331D297D2B31Q28367552-4E464223-4C25-4154-B67A-81A3773B23AAQ28367707-7FCEE61C-2385-46AE-9273-03774E1B38F7Q28368045-69EEA013-C452-44BF-9186-3554A81CEF1CQ28369309-27B49E4F-A0CB-4243-926D-AE31A30CEC9EQ28376938-4A15C32A-9704-419A-B2B8-2404C15C0BB2Q34770674-D49C4195-99CB-4731-85AA-1C56D10030DAQ34779869-93FB2EC9-467F-45B3-8372-A07D5D9AECADQ35322871-1AF76924-B939-4D72-B869-5E49BBC4E0DAQ40324262-AA69503E-A157-43CA-B9F3-AF0277A3FA07Q40338429-67FB0491-9CA2-480B-93D9-930F8616832BQ40534064-B95B3E1C-FD02-43F1-954D-360350CB77DEQ42251913-E76769C4-4FD0-4E7E-AE6E-D11A661F8804Q43503280-B1A094E9-B888-430A-A576-1D7221C39666Q43510541-6560EB12-EA18-452D-9F86-5A019887B0C3Q43630595-3B4DB7C6-7561-43FA-BC3C-7A6E5C924E84Q44246955-FEE6E513-CEFA-4E7D-8662-B71350EABC76Q47977270-878934FE-D027-4D30-9335-FB6C2E73A19B
P2860
A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)
description
1991 nî lūn-bûn
@nan
1991 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
A new class of HIV-1-specific ...... ]-6-(phenylthio)thymine (HEPT)
@ast
A new class of HIV-1-specific ...... ]-6-(phenylthio)thymine (HEPT)
@en
A new class of HIV-1-specific ...... ]-6-(phenylthio)thymine (HEPT)
@nl
type
label
A new class of HIV-1-specific ...... ]-6-(phenylthio)thymine (HEPT)
@ast
A new class of HIV-1-specific ...... ]-6-(phenylthio)thymine (HEPT)
@en
A new class of HIV-1-specific ...... ]-6-(phenylthio)thymine (HEPT)
@nl
prefLabel
A new class of HIV-1-specific ...... ]-6-(phenylthio)thymine (HEPT)
@ast
A new class of HIV-1-specific ...... ]-6-(phenylthio)thymine (HEPT)
@en
A new class of HIV-1-specific ...... ]-6-(phenylthio)thymine (HEPT)
@nl
P2093
P356
P1476
A new class of HIV-1-specific ...... ]-6-(phenylthio)thymine (HEPT)
@en
P2093
H Hayakawa
H Takashima
T Miyasaka
T Sakamaki
P304
P356
10.1021/JM00105A055
P407
P577
1991-01-01T00:00:00Z