Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds
about
Comparison of in vitro biological properties and mouse toxicities of three thymidine analogs active against human immunodeficiency virusIntracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compoundNovel mutation (V75T) in human immunodeficiency virus type 1 reverse transcriptase confers resistance to 2',3'-didehydro-2',3'-dideoxythymidine in cell cultureMechanism of anti-HIV action of masked alaninyl d4T-MP derivativesAntiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newbS-1153 inhibits replication of known drug-resistant strains of human immunodeficiency virus type 1Intracellular zidovudine (ZDV) and ZDV phosphates as measured by a validated combined high-pressure liquid chromatography-radioimmunoassay procedure.Enzymatic assay for measurement of zidovudine triphosphate in peripheral blood mononuclear cells.Comparison of rates of intracellular metabolism of zidovudine in human and primate peripheral blood mononuclear cells.Behavior of thymidylate kinase toward monophosphate metabolites and its role in the metabolism of 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (Clevudine) and 2',3'-didehydro-2',3'-dideoxythymidine in cells.SAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors.Determinants of individual variation in intracellular accumulation of anti-HIV nucleoside analog metabolites.Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.Population pharmacokinetics of stavudine (d4T) in patients with AIDS or advanced AIDS-related complexMechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcriptionMutants of feline immunodeficiency virus resistant to 2',3'-dideoxy-2',3'-didehydrothymidine.Antiviral therapy for human immunodeficiency virus infectionsIntracellular trafficking of hybrid gene delivery vectorsComparison of the phosphorylation of 4'-ethynyl 2',3'-dihydro-3'-deoxythymidine with that of other anti-human immunodeficiency virus thymidine analogs.In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine.HIV-1 antiretroviral drug therapy.Effects of 3'-deoxynucleoside 5'-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type 1 reverse transcription of minus-strand strong-stop DNAInhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs.Synthesis and anti-HIV activities of bis-(cycloSaligenyl) pronucleotides derivatives of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine.Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering.Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations.Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro.Evidence of alkaline phosphatase interference in a zidovudine radioimmunoassay.Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis.Anticancer conjugates and cocktails based on methotrexate and nucleoside synergism.Synthesis, characterization, and in vitro assay of folic acid conjugates of 3'-azido-3'-deoxythymidine (AZT): toward targeted AZT based anticancer therapeutics.Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antiviralsMechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase.Nucleoside Sensing.Nucleoside diphosphate and triphosphate prodrugs - An unsolvable task?Genetic Variation of the Kinases that Phosphorylate Tenofovir and Emtricitabine in Peripheral Blood Mononuclear Cells.
P2860
Q28323353-FFE0F158-A032-4822-963F-DC97EE447B9AQ28323687-853076EC-419E-4A04-8912-21A813D196D4Q28367594-9172FD86-9627-426D-B7E5-CBB0978C5F6BQ28378931-B6700BEE-CE53-4899-8974-CD0DD0621356Q28379501-64038C73-EF31-410E-B58F-794F58FF1DD5Q28379544-13FE6F68-9CBB-4D84-9878-09F67BF17D4CQ33745545-D82851C6-ED26-47F7-9D20-7CED02A25F65Q33747461-124C20BE-A22F-47C6-8153-C1F4168D2E03Q33761409-62C7C38C-A441-4766-A608-8F1A605E5555Q33769957-0BD9A605-04C7-49EC-B6DB-8A153C9A477CQ34058234-ED5FA700-1350-47BC-AAE3-52DC4B84F7F9Q34529268-C29B2D1D-3BD7-4C88-86FD-68F13AF64979Q34757980-68723062-F2B3-4831-BBAA-A8FCD8BDD65DQ35119768-D8BB611A-7669-4395-88AF-29A2993ABD83Q35122784-3BB3ADBD-980E-4840-AF7D-6C62924E29AAQ35126454-294F55FA-338E-42A8-889F-3CFBC3C6D70EQ35366050-8C8CF0D3-421D-4518-8886-A351DA757E81Q35602437-0BD02423-21B9-42C0-BAB8-9774B0E79F90Q35759090-7CC2139D-C077-429E-8904-9A7D01C336CAQ35818961-4E6948FD-F628-4448-9D93-9B434948B4CFQ35853012-C95F2CDF-D1DE-4265-9FFA-992FA316C415Q35854248-9336D4BA-CDF2-40B7-8E0C-CA6EFF87C7DDQ35903936-4D71A93C-D5E0-41E4-8AF9-9E4ECE539293Q36362416-D10BCB81-7633-4192-B912-C6A1FA457FD2Q37619470-18046B05-6D81-4D10-9827-9AB3E5500731Q39657826-8ABBAE5A-D42F-45C6-8BFC-549BDF8D6341Q39784283-3FF6F674-C963-4118-A458-BD2A4D37D5C8Q39867324-7C54C493-72A2-4EED-B1CB-7019AF974476Q39867349-07C70DD1-78B5-47FF-A117-07B7188CF959Q39900240-F811F4F8-C844-47B5-8388-F0BEB8A9E257Q40023090-CB936385-CCFA-41D1-A61E-AE0812BBF110Q40138976-733638CA-033A-4656-8935-C651857C78D2Q40936332-94BD19AC-22B7-4821-8BDF-72182461C04FQ42277625-9DA2B56F-ACCA-42DD-92FF-AA679BD8EEE4Q45842575-99B84190-D329-4159-8C24-7DB5CDF948FBQ47592519-6A55D458-4648-4BFE-97C8-798BB5C41CFCQ49888809-365DC639-F8CA-43A9-B393-94D3891F17A8
P2860
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds
description
1989 nî lūn-bûn
@nan
1989 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Differential patterns of intra ...... munodeficiency virus compounds
@ast
Differential patterns of intra ...... munodeficiency virus compounds
@en
Differential patterns of intra ...... munodeficiency virus compounds
@nl
type
label
Differential patterns of intra ...... munodeficiency virus compounds
@ast
Differential patterns of intra ...... munodeficiency virus compounds
@en
Differential patterns of intra ...... munodeficiency virus compounds
@nl
prefLabel
Differential patterns of intra ...... munodeficiency virus compounds
@ast
Differential patterns of intra ...... munodeficiency virus compounds
@en
Differential patterns of intra ...... munodeficiency virus compounds
@nl
P1476
Differential patterns of intra ...... munodeficiency virus compounds
@en
P2093
E De Clercq
P Herdewijn
P304
P407
P577
1989-04-15T00:00:00Z