Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells - Wikidata - wikimedia - TriplyDB

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

http://www.wikidata.org/entity/Q28344025

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A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1.ARK5 is a tumor invasion-associated factor downstream of Akt signaling Mechanotransduction in skeletal muscle Increased expression of integrin-linked kinase is associated with shorter survival in non-small cell lung cancer PTEN deficiency: a role in mammary carcinogenesis.Posttranslational regulation of Akt in human cancer PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer Downregulation of Akt1 inhibits anchorage-independent cell growth and induces apoptosis in cancer cells Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes "Topological significance" analysis of gene expression and proteomic profiles from prostate cancer cells reveals key mechanisms of androgen response The Novel Small Molecule Inhibitor, OSU-T315, Suppresses Vestibular Schwannoma and Meningioma Growth by Inhibiting PDK2 Function in the AKT Pathway Activation Integrin-linked kinase is required for epidermal and hair follicle morphogenesis.Integrin-linked kinase controls neurite outgrowth in N1E-115 neuroblastoma cells.Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target.Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.Significance of talin in cancer progression and metastasis.Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma.Integrin involvement in freeze resistance of androgen-insensitive prostate cancer.The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer.Identification and characterization of a novel integrin-linked kinase inhibitor Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells.Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1.3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process.Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival.Maspin regulates endothelial cell adhesion and migration through an integrin signaling pathway.Role of AKT signaling in DNA repair and clinical response to cancer therapy.Expression of parvin-beta is a prognostic factor for patients with urothelial cell carcinoma of the upper urinary tract.Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1 ILK mediates the effects of strain on intestinal epithelial wound closure 4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management.Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines.Modulation of integrin-linked kinase (ILK) expression in human oesophageal squamous cell carcinoma cell lines by the EGF and TGFbeta1 growth factors.Matrix-dependent regulation of AKT in Hepsin-overexpressing PC3 prostate cancer cells.Mechanical stimuli and IL-13 interact at integrin adhesion complexes to regulate expression of smooth muscle myosin heavy chain in airway smooth muscle tissue.Genistein exerts anti-leukemic effects on genetically different acute myeloid leukemia cell lines by inhibiting protein synthesis and cell proliferation while inducing apoptosis - molecular insights from an iTRAQ™ quantitative proteomics study.Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice.

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Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

http://www.wikidata.org/entity/Q28344025

description

2000 nî lūn-bûn

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2000 թուականի Մարտին հրատարակուած գիտական յօդուած

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2000 թվականի մարտին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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Inhibition of integrin-linked ...... N-mutant prostate cancer cells

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Inhibition of integrin-linked ...... N-mutant prostate cancer cells

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Inhibition of integrin-linked ...... N-mutant prostate cancer cells

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type

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Inhibition of integrin-linked ...... N-mutant prostate cancer cells

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Inhibition of integrin-linked ...... N-mutant prostate cancer cells

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Inhibition of integrin-linked ...... N-mutant prostate cancer cells

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Inhibition of integrin-linked ...... N-mutant prostate cancer cells

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Inhibition of integrin-linked ...... N-mutant prostate cancer cells

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Inhibition of integrin-linked ...... N-mutant prostate cancer cells

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Proceedings of the National Academy of Sciences of the United States of America

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Inhibition of integrin-linked ...... N-mutant prostate cancer cells

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A Troussard

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J Sanghera

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M Delcommenne

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S Attwell

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S Dedhar

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S Persad

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V Gray

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Direct control of the Forkhead transcription factor AFX by protein kinase B

Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways

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3207-12

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751610

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10.1073/PNAS.060579697

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7

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97

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24447948

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10716737

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16217

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