Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy
about
A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosismda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.Enhanced apoptosis-inducing function of MDA-7/IL-24 RGD mutant via the increased adhesion to tumor cells.MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer.Enhanced SOX2 expression in retinoblastoma tissues and peripheral blood is associated with the clinicopathological characteristics of the diseaseSplice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells.IL-24 inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axismda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokineMDA-7/IL-24 suppresses human ovarian carcinoma growth in vitro and in vivo.IL-2 regulates the expression of the tumor suppressor IL-24 in melanoma cells.Molecular Mechanisms Governing IL-24 Gene Expression.Insulin-like growth factor binding protein-3 mediates interleukin-24-induced apoptosis through inhibition of the mTOR pathway in prostate cancer.Development of Ad-mda7/IL-24-resistant lung cancer cell lines.Construction of expressing vectors including melanoma differentiation-associated gene-7 (mda-7) fused with the RGD sequences for better tumor targetingRNA-binding protein CELF1 promotes tumor growth and alters gene expression in oral squamous cell carcinoma.Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing.MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells.Induction of cytokine gene expression in human thyroid epithelial cells irradiated with HZE particles (iron ions).IL-24 modulates the high mobility group (HMG) A1/miR222 /AKT signaling in lung cancer cells.HDAC4 inhibits the transcriptional activation of mda-7/IL-24 induced by Sp1.Molecular targets and signaling pathways regulated by interleukin (IL)-24 in mediating its antitumor activities.Phosphorylation of interleukin (IL)-24 is required for mediating its anti-cancer activityInterleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells.Killing of human melanoma cells induced by activation of class I interferon-regulated signaling pathways via MDA-7/IL-24.Cancer Terminator Viruses (CTV): A Better Solution for Viral-Based Therapy of Cancer.
P2860
Q28509494-8CD23856-3766-4B7C-A880-AD76DE0CEB0FQ34098956-50A01AAB-B02B-4322-A245-DDFFCB9EE455Q34128541-06EA140F-1F9B-4AC7-B92B-77E47AE4ACE7Q34133056-918EF114-CA67-49C6-B7C5-611EF976903EQ35042144-1B57D0BB-EE9B-460B-A522-FD5BA1087012Q35256043-F1A00987-D670-42CB-98C3-3EB4685E73E4Q35578377-8B227641-A399-4FD1-A07B-FEDC8C38FFF8Q35609031-DE51D653-BDC4-45C7-B398-D37276D6B9E7Q35633270-0AE9EFE3-1D49-4C51-8C40-D800C4D7B9BCQ35661491-9EDE38BE-3B36-4440-94F3-69EC973A3CF1Q35897587-7D6AAC80-B758-442E-9765-7ADD6E43F246Q36094078-9CE5F5AC-6155-4847-B2F6-A303D16F6794Q36235233-F61B5E32-FEA4-4AEA-B6F4-573E41176A2DQ36249337-EF9218D1-3889-46B2-B561-AEE8A1014F9DQ36685461-F60CAA3E-60E9-46DC-820E-625CD2427721Q37001673-9D5DBE45-0FF6-4EBE-9256-0BF27F5209EAQ37419724-EE14B043-EF98-4AB4-B6CC-FF986337DE68Q37467039-E800C550-C5E1-461F-8188-EAC08650F99BQ37688519-D2999A73-A144-491E-8B27-657A978C4E94Q37729116-AC3A3D6B-59CD-4486-91DE-AAC4797C96DDQ38174692-E9E4944D-649A-487E-AB7C-AB115984DDDBQ38871014-D33552AA-38F1-417B-8EA1-EDD41FB8FB0CQ39908793-09C107D3-EC3E-4950-B388-B858CFB7C110Q39977288-CA56B3AF-0D74-40F2-9658-C711125291D1Q47560447-3E6B6048-0C9B-4877-81BC-FAC3F3A2AF33
P2860
Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Melanoma differentiation assoc ...... r gene for cancer gene therapy
@ast
Melanoma differentiation assoc ...... r gene for cancer gene therapy
@en
Melanoma differentiation assoc ...... r gene for cancer gene therapy
@nl
type
label
Melanoma differentiation assoc ...... r gene for cancer gene therapy
@ast
Melanoma differentiation assoc ...... r gene for cancer gene therapy
@en
Melanoma differentiation assoc ...... r gene for cancer gene therapy
@nl
prefLabel
Melanoma differentiation assoc ...... r gene for cancer gene therapy
@ast
Melanoma differentiation assoc ...... r gene for cancer gene therapy
@en
Melanoma differentiation assoc ...... r gene for cancer gene therapy
@nl
P2093
P356
P1433
P1476
Melanoma differentiation assoc ...... r gene for cancer gene therapy
@en
P2093
A M Mhashilkar
F Kourouma
G J Watson
P2888
P304
P356
10.1007/BF03401847
P407
P577
2001-04-01T00:00:00Z