Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR - Wikidata - wikimedia - TriplyDB

Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR

Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR

http://www.wikidata.org/entity/Q28361576

about

Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae.Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin Mds3 regulates morphogenesis in Candida albicans through the TOR pathway The protein kinase Tor1 regulates adhesin gene expression in Candida albicans Role of Ess1 in growth, morphogenetic switching, and RNA polymerase II transcription in Candida albicans Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus Antifungal activities of tacrolimus and azole agents against the eleven currently accepted Malassezia species Antifungal application of nonantifungal drugs Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires.Importance of microbial natural products and the need to revitalize their discovery.Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants The TOR signal transduction cascade controls cellular differentiation in response to nutrients.Hyphal development in Candida albicans requires two temporally linked changes in promoter chromatin for initiation and maintenance.Calcineurin is essential for survival during membrane stress in Candida albicans.Modulation of morphogenesis in Candida albicans by various small molecules.Monitoring molecular-specific pharmacodynamics of rapamycin in vivo with inducible Gal4->Fluc transgenic reporter mice.Regulation of Hxt3 and Hxt7 turnover converges on the Vid30 complex and requires inactivation of the Ras/cAMP/PKA pathway in Saccharomyces cerevisiae Calcineurin inhibitors and rapamycin: cancer protection or promotion?Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei.Direct effects of non-antifungal agents used in cancer chemotherapy and organ transplantation on the development and virulence of Candida and Aspergillus species Rhb1 regulates the expression of secreted aspartic protease 2 through the TOR signaling pathway in Candida albicans.Dual action antifungal small molecule modulates multidrug efflux and TOR signaling Combined image guided monitoring the pharmacokinetics of rapamycin loaded human serum albumin nanoparticles with a split luciferase reporter Reduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity.The structure of the Candida albicans Ess1 prolyl isomerase reveals a well-ordered linker that restricts domain mobility The role and value of sirolimus administration in kidney and liver transplantation.Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.Diverse Hap43-independent functions of the Candida albicans CCAAT-binding complex.Shuttle vectors for facile gap repair cloning and integration into a neutral locus in Candida albicans.Calcineurin regulation in fungi and beyond Combination therapeutic approaches for the management of invasive aspergillosis in organ transplant recipients.Old Cryptococcus neoformans cells contribute to virulence in chronic cryptococcosis.Cryptococcus neoformans constitutes an ideal model organism to unravel the contribution of cellular aging to the virulence of chronic infections.GLN3 encodes a global regulator of nitrogen metabolism and virulence of C. albicans.Signaling cascades as drug targets in model and pathogenic fungi.In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes.Inhibitors of cellular signalling are cytotoxic or block the budded-to-hyphal transition in the pathogenic yeast Candida albicans.Our paths might cross: the role of the fungal cell wall integrity pathway in stress response and cross talk with other stress response pathways.In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.

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Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR

http://www.wikidata.org/entity/Q28361576

description

2001 nî lūn-bûn

@nan

2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2001 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR

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Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR

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Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR

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type

label

Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR

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Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR

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Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR

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prefLabel

Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR

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Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR

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Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR

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AAC.45.11.3162-3170.2001

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Antimicrobial Agents and Chemotherapy

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Rapamycin and less immunosuppr ...... 12-dependent inhibition of TOR

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P2093

A L Goldstein

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J Blankenship

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J H McCusker

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J Heitman

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J R Perfect

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M C Cruz

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M Del Poeta

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M E Cardenas

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Y L Bennani

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P2860

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

Tor-mediated induction of autophagy via an Apg1 protein kinase complex

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors.

FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.

TOR controls translation initiation and early G1 progression in yeast

Green fluorescent protein as a marker for gene expression and subcellular localization in budding yeast.

Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae.

Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases.

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3162-70

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infectious disease

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