BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity - Wikidata - wikimedia - TriplyDB

BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity

BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity

http://www.wikidata.org/entity/Q28362867

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mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR Cyclothiazide selectively inhibits mGluR1 receptors interacting with a common allosteric site for non-competitive antagonists Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors Allosteric modulation of metabotropic glutamate receptors.Metabotropic glutamate receptors: from the workbench to the bedside.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Serum glutamate levels correlate with Gleason score and glutamate blockade decreases proliferation, migration, and invasion and induces apoptosis in prostate cancer cells Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells.Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors.Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation Delayed stabilization of dendritic spines in fragile X mice.Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice.The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor Cooperative signaling between homodimers of metabotropic glutamate receptors 1 and 5 Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery Mechanisms of tau and Aβ-induced excitotoxicity.G protein coupled receptor structure and activation Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQ(Q209L)-driven melanoma.Functional analysis of human cytomegalovirus pUS28 mutants in infected cells.Neurotransmitter signaling pathways required for normal development in Xenopus laevis embryos: a pharmacological survey screen Optical measurement of mGluR1 conformational changes reveals fast activation, slow deactivation, and sensitization.Agonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domains Metabotropic glutamate receptor ligands as potential therapeutics for addiction Allosteric modulators for mGlu receptors.Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective.Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer.Metabotropic glutamate receptors: physiology, pharmacology, and disease.Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indications Molecular Basis for Modulation of Metabotropic Glutamate Receptors and Their Drug Actions by Extracellular Ca2 Constitutive activity modulation of human metabotropic glutamate 5a receptors in HEK293 cells: a role for key amino-terminal cysteine residues.Differential modulation of the lactisole 'Sweet Water Taste' by sweeteners.Metabotropic glutamate receptors: potential drug targets for psychiatric disorders.

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BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity

http://www.wikidata.org/entity/Q28362867

description

2001 nî lūn-bûn

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2001 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2001 թվականի մայիսին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

BAY36-7620: a potent non-compe ...... with inverse agonist activity

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BAY36-7620: a potent non-compe ...... with inverse agonist activity

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BAY36-7620: a potent non-compe ...... with inverse agonist activity

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BAY36-7620: a potent non-compe ...... with inverse agonist activity

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BAY36-7620: a potent non-compe ...... with inverse agonist activity

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BAY36-7620: a potent non-compe ...... with inverse agonist activity

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BAY36-7620: a potent non-compe ...... with inverse agonist activity

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BAY36-7620: a potent non-compe ...... with inverse agonist activity

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BAY36-7620: a potent non-compe ...... with inverse agonist activity

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Molecular Pharmacology

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BAY36-7620: a potent non-compe ...... with inverse agonist activity

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Antonicek H

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Beart PM

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Bockaert J

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Brabet I

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Carroll FY

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Joly C

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Prézeau L

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Stolle A

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P2860

G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C

Molecular tinkering of G protein-coupled receptors: an evolutionary success

Measurement of protein using bicinchoninic acid

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

The two-state model of receptor activation

Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding

Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor

Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain

Pharmacology and functions of metabotropic glutamate receptors

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965-973

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scholarly article

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1290425

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10.1124/MOL.59.5.965

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5

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59

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Jean-Philippe Pin

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2001-05-01T00:00:00Z

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11306677

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2573968

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