Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
about
Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemiaDiabetes outfoxed by GLP-1?Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB betaInsulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomeMechanisms of action of glucagon-like peptide 1 in the pancreasBeneficial Renal and Pancreatic Phenotypes in a Mouse Deficient in FXYD2 Regulatory Subunit of Na,K-ATPaseRole of AKT/mTORC1 pathway in pancreatic β-cell proliferationNatural history of β-cell adaptation and failure in type 2 diabetesCell biology. On being the right (cell) sizeThyroid hormone T3 counteracts STZ induced diabetes in mousePerinatal bisphenol A exposure and adult glucose homeostasis: identifying critical windows of exposureFoxO1 mediates insulin-dependent regulation of hepatic VLDL production in micePhosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-CellsAdenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replicationRibosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis.Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcriptionNkx2.2 regulates beta-cell function in the mature isletRole of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growthTrefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.Importance of β-Catenin in glucose and energy homeostasis.Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistanceActivation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors.Pancreatic β-cell proliferation in obesity.Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass.A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathwaysSlow and steady is the key to beta-cell replication.Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia.Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinasesDiscovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening.Role of nutrients and mTOR signaling in the regulation of pancreatic progenitors development.PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors.Insulin secretion and insulin-producing tumorsGlucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.A vicious partnership between AKT and PHLDA3 to facilitate neuroendocrine tumors.Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function.Glial cell line-derived neurotrophic factor enhances neurogenin3 gene expression and beta-cell proliferation in the developing mouse pancreas.Exendin-4 protects oxidative stress-induced β-cell apoptosis through reduced JNK and GSK3β activity.Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring.
P2860
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P2860
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Islet beta cell expression of ...... erplasia, and hyperinsulinemia
@ast
Islet beta cell expression of ...... erplasia, and hyperinsulinemia
@en
Islet beta cell expression of ...... erplasia, and hyperinsulinemia
@nl
type
label
Islet beta cell expression of ...... erplasia, and hyperinsulinemia
@ast
Islet beta cell expression of ...... erplasia, and hyperinsulinemia
@en
Islet beta cell expression of ...... erplasia, and hyperinsulinemia
@nl
prefLabel
Islet beta cell expression of ...... erplasia, and hyperinsulinemia
@ast
Islet beta cell expression of ...... erplasia, and hyperinsulinemia
@en
Islet beta cell expression of ...... erplasia, and hyperinsulinemia
@nl
P2093
P2860
P3181
P356
P1476
Islet beta cell expression of ...... erplasia, and hyperinsulinemia
@en
P2093
C M Welling
E Bernal-Mizrachi
M A Permutt
S Stahlhut
P2860
P304
P3181
P356
10.1172/JCI13785
P407
P577
2001-12-01T00:00:00Z