Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats--pharmacokinetic/pharmacodynamic modelling - Wikidata - wikimedia - TriplyDB

Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats--pharmacokinetic/pharmacodynamic modelling

Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats--pharmacokinetic/pharmacodynamic modelling

http://www.wikidata.org/entity/Q28366078

about

Contribution of the active metabolite M1 to the pharmacological activity of tesofensine in vivo: a pharmacokinetic-pharmacodynamic modelling approach How to measure drug transport across the blood-brain barrier The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication.Role of morphine's metabolites in analgesia: concepts and controversies.Blood-brain distribution of morphine-6-glucuronide in sheep.Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling.Morphine-6-glucuronide (M6G) for postoperative pain relief.On the rate and extent of drug delivery to the brain.Physiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approach Morphine metabolism, transport and brain disposition.Application of microdialysis for pharmacokinetic-pharmacodynamic modelling.Understanding the hysteresis loop conundrum in pharmacokinetic/pharmacodynamic relationships.Opioids and the blood-brain barrier: a dynamic interaction with consequences on drug disposition in brain.Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of norfloxacin in rats.Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux.Simultaneous central nervous system distribution and pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats.Different distribution of morphine and morphine-6 beta-glucuronide after intracerebroventricular injection in rats.Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein.Effect of 12-oxochenodeoxycholate on the pharmacokinetics and pharmacodynamics of morphine 6-glucuronide in Wistar rats.

P2860

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P2860

Blood-brain barrier transport and brain distribution of morphine-6-glucuronide in relation to the antinociceptive effect in rats--pharmacokinetic/pharmacodynamic modelling

http://www.wikidata.org/entity/Q28366078

description

2001 nî lūn-bûn

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2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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Blood-brain barrier transport ...... etic/pharmacodynamic modelling

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Blood-brain barrier transport ...... etic/pharmacodynamic modelling

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Blood-brain barrier transport ...... etic/pharmacodynamic modelling

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Blood-brain barrier transport ...... etic/pharmacodynamic modelling

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Blood-brain barrier transport ...... etic/pharmacodynamic modelling

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Blood-brain barrier transport ...... etic/pharmacodynamic modelling

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Blood-brain barrier transport ...... etic/pharmacodynamic modelling

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Blood-brain barrier transport ...... etic/pharmacodynamic modelling

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British Journal of Pharmacology

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Blood-brain barrier transport ...... etic/pharmacodynamic modelling

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P2093

K Tunblad

http://www.w3.org/2001/XMLSchema#string

M Hammarlund-Udenaes

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M R Bouw

http://www.w3.org/2001/XMLSchema#string

R Xie

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P2860

An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites

Diffusion of morphine-6-beta-D-glucuronide into the neonatal guinea pig brain during drug-induced respiratory depression.

Testing computer-controlled infusion pumps by simulation.

Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum.

Comparison of four basic models of indirect pharmacodynamic responses

Multiple mu opiate receptors.

The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice.

Modelling of the blood-brain barrier transport of morphine-3-glucuronide studied using microdialysis in the rat: involvement of probenecid-sensitive transport.

Elevated concentrations of morphine 6-beta-D-glucuronide in brain extracellular fluid despite low blood-brain barrier permeability.

Morphine-6-glucuronide has high affinity for the opioid receptor.

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1796-804

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scholarly article

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10.1038/SJ.BJP.0704406

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8

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134

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11739257

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P921

blood–brain barrier

pharmacokinetics

pharmacodynamics

P932

1572896

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