New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs - Wikidata - wikimedia - TriplyDB

New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs

New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs

http://www.wikidata.org/entity/Q28367654

about

Non-nucleoside reverse transcriptase inhibitors: a review on pharmacokinetics, pharmacodynamics, safety and tolerability Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors Patterns of resistance and cross-resistance to human immunodeficiency virus type 1 reverse transcriptase inhibitors in patients treated with the nonnucleoside reverse transcriptase inhibitor loviride SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus Non-nucleoside reverse transcriptase inhibitors: the NNRTI boom.In search of a selective antiviral chemotherapy.Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression.The discovery of antiviral agents: ten different compounds, ten different stories.Defining a molecular mechanism of synergy between nucleoside and nonnucleoside AIDS drugs.The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study.Antiviral Chemistry & Chemotherapy's current antiviral agents FactFile (2nd edition): retroviruses and hepadnaviruses.Design, synthesis, biological evaluation, and molecular modeling studies of TIBO-like cyclic sulfones as non-nucleoside HIV-1 reverse transcriptase inhibitors.Imidazo[1,5-b]pyridazine-d4T conjugates: synthesis and anti-human immunodeficiency virus evaluation.Broad-spectrum antiviral activity and mechanism of antiviral action of the fluoroquinolone derivative K-12.A check on rational drug design: molecular simulation of the allosteric inhibition of HIV-1 reverse transcriptase.The combined anti-HIV-1 activities of emtricitabine and tenofovir plus the integrase inhibitor elvitegravir or raltegravir show high levels of synergy in vitro.What can be Expected from Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) in the Treatment of Human Immunodeficiency Virus Type 1 (HIV-1) Infections?Computational modeling of tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepinone derivatives: an atomistic drug design approach using Kier-Hall electrotopological state (E-state) indices.Conformation depends on 4D-QSAR analysis using EC-GA method: pharmacophore identification and bioactivity prediction of TIBOs as non-nucleoside reverse transcriptase inhibitors.Long-read direct infrared sequencing of crude PCR products for prediction of resistance to HIV-1 reverse transcriptase and protease inhibitors.

P2860

Q24628212-CEF5AEB2-18C1-40BA-A02C-DEF9B9F6AB04 Q27729437-D1F82F53-0E14-4630-BB87-F1F318D96FD5 Q28369293-676FCE5D-C1CB-4420-8BAC-67CEFC63C2D7 Q28379459-136A4776-23FF-43A5-A212-E000A72EA1F1 Q33813305-2AEA3E78-FDD2-4288-B8F4-3624885FD315 Q35375912-F1967490-6A22-4903-977E-BDCE96AA8281 Q35600919-C09762C4-C3CA-402B-B065-A5AE3B5A47BB Q37148421-EBCBD2B4-E8B4-451F-A36A-4B0E89769541 Q38346006-6EBFFA1F-EFCC-447A-9BF2-4B59EEE29C4E Q39852169-F5D8F26D-9474-441F-97CE-280229F5EDB8 Q40055204-2AAC39B7-68EE-4A75-A7CB-60D4F8096DC8 Q40246588-926185D7-FD8E-4E75-A64B-86A26112D18A Q40983879-0FB0203C-A1A8-4D34-8425-5C75904730CC Q40983909-FEC8AC6E-9BA8-4C13-9CA5-FC5F20F57445 Q41452204-53BA86A6-1D00-4BBF-81AB-E7B4B2CE6983 Q42932779-26578D27-DCD7-4B84-A6B7-76FE32F8B9F6 Q45748524-ABAF4341-01EB-4D49-BD7C-85FB9441F2F5 Q46693308-AA3BA4E1-2B1A-495E-A5F8-5886FF671EAE Q51367473-459F9EBE-CCF8-4D1E-8DD0-7A08B576A914 Q54120801-AA9215B5-0C02-4C76-8C11-42C6190154F9

P2860

New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs

http://www.wikidata.org/entity/Q28367654

description

1994 nî lūn-bûn

@nan

1994 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1994 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

1994年の論文

@ja

1994年論文

@yue

1994年論文

@zh-hant

1994年論文

@zh-hk

1994年論文

@zh-mo

1994年論文

@zh-tw

1994年论文

@wuu

name

New tetrahydroimidazo[4,5,1-jk ...... ',3'-dideoxynucleoside analogs

@ast

New tetrahydroimidazo[4,5,1-jk ...... ',3'-dideoxynucleoside analogs

@en

New tetrahydroimidazo[4,5,1-jk ...... ',3'-dideoxynucleoside analogs

@nl

type

label

New tetrahydroimidazo[4,5,1-jk ...... ',3'-dideoxynucleoside analogs

@ast

New tetrahydroimidazo[4,5,1-jk ...... ',3'-dideoxynucleoside analogs

@en

New tetrahydroimidazo[4,5,1-jk ...... ',3'-dideoxynucleoside analogs

@nl

prefLabel

New tetrahydroimidazo[4,5,1-jk ...... ',3'-dideoxynucleoside analogs

@ast

New tetrahydroimidazo[4,5,1-jk ...... ',3'-dideoxynucleoside analogs

@en

New tetrahydroimidazo[4,5,1-jk ...... ',3'-dideoxynucleoside analogs

@nl

P1433

Q28367654-82EA7F65-C2AD-468F-A892-6915E998D3E3

P1476

Q28367654-80FF1645-D462-4517-8FD5-C801F6AD01F9

P2093

Q28367654-2994CF60-2149-423E-B120-7F26A967D715

Q28367654-2CD72081-4140-4CE3-9C90-05C01A66A590

Q28367654-3AAB0ED6-2A15-4C56-8DC0-8C646625B70B

Q28367654-55853A71-4D68-4B63-A72C-E7F34A31ECE8

Q28367654-6A66F629-C938-44B1-8FD1-9363C706013C

Q28367654-C9921622-2CDA-4D4D-8471-D79E9C34E91E

Q28367654-E4EF2ED5-2054-4C86-B86B-E56296C680D7

Q28367654-F293C5F0-F260-419F-A101-82A309EFFA40

Q28367654-FB348310-53F0-4FC0-8B36-DAF7F1D41603

P2860

Q28367654-079E83B3-FB77-4C8E-8DF5-AFC7BA102160

Q28367654-0E3BC7E9-D03C-49F6-A1BA-9DFC50573511

Q28367654-0EA94098-EDB2-4B20-932A-A86CCFC28BE8

Q28367654-14A48CE0-63BF-4BB2-802F-651E57486942

Q28367654-1D070633-BFCF-4D42-BE9B-2A9F4EDBF611

Q28367654-1FF98193-E423-4ACE-B3A5-C2545F87A2D8

Q28367654-2355036D-9F65-47ED-9F2F-97C29B3C5C26

Q28367654-24D09713-37C6-4CC1-B30D-32023C3192C4

Q28367654-266D2DBA-48D7-4FEF-92F2-CD74FA730E7D

Q28367654-282327DB-DA51-4F44-BE00-EFF300113825

P304

Q28367654-A9FE583F-C4FF-440B-82A2-3AC4CFD5E2CE

P31

Q28367654-C5EB72D6-FED0-432E-AF93-D946E1BCDD1B

P356

Q28367654-7DFA8038-E99C-42E6-8E90-FA6F49775A17

P407

Q28367654-9E7E0491-87B3-4CD8-8097-90EA88053EAD

P433

Q28367654-32B95389-A376-4792-A386-3E63B31ED2E6

P478

Q28367654-DDC14520-AA82-4D2B-95B3-C249EEFF959A

P50

Q28367654-2EA17084-F1D1-4514-A94E-97FC2EA508AB

P577

Q28367654-4EC4A5E6-9B40-4052-A7AD-981D048110BD

P698

Q28367654-D67DB428-8119-48F0-97C5-239ED7CAC8EC

P932

Q28367654-D03C4389-90E2-447C-8ECE-B4D2752D6C95

P356

P1433

Antimicrobial Agents and Chemotherapy

P1476

New tetrahydroimidazo[4,5,1-jk ...... ',3'-dideoxynucleoside analogs

@en

P2093

D Schols

http://www.w3.org/2001/XMLSchema#string

H J Breslin

http://www.w3.org/2001/XMLSchema#string

J Desmyter

http://www.w3.org/2001/XMLSchema#string

K Andries

http://www.w3.org/2001/XMLSchema#string

M A Janssen

http://www.w3.org/2001/XMLSchema#string

M J Kukla

http://www.w3.org/2001/XMLSchema#string

R Pauwels

http://www.w3.org/2001/XMLSchema#string

R Woestenborghs

http://www.w3.org/2001/XMLSchema#string

Z Debyser

http://www.w3.org/2001/XMLSchema#string

P2860

In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase

Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis

Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)t

Differential inhibitory effects of TIBO derivatives on different strains of simian immunodeficiency virus

[2',5'-Bis-O-(tert-butyldimethylsilyl)]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) (TSAO) derivatives of purine and pyrimidinenucleosides as potent and selective inhibitors of human immunodeficiency virus type 1

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor

An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives

BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine

Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity

P304

2863-70

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/AAC.38.12.2863

http://www.w3.org/2001/XMLSchema#string

P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

38

http://www.w3.org/2001/XMLSchema#string

P50

P577

1994-12-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

7535037

http://www.w3.org/2001/XMLSchema#string

P932

188298

http://www.w3.org/2001/XMLSchema#string