Electron paramagnetic resonance evidence for binding of Cu(2+) to the C-terminal domain of the murine prion protein
about
The PrP-like protein Doppel binds copperUtilizing NMR and EPR spectroscopy to probe the role of copper in prion diseases.Mapping Cu(II) binding sites in prion proteins by diethyl pyrocarbonate modification and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometric footprinting.Copper(II) binding to the human Doppel protein may mark its functional diversity from the prion protein.Insights into prion protein function from atomistic simulations.Copper binding extrinsic to the octarepeat region in the prion proteinStability and Cu(II) binding of prion protein variants related to inherited human prion diseases.Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions.Copper binding in the prion proteinTrace elements and prion diseases: a review of the interactions of copper, manganese and zinc with the prion protein.Zinc modulates copper coordination mode in prion protein octa-repeat subdomains.Functional implications of multistage copper binding to the prion protein.Regulation of prion gene expression by transcription factors SP1 and metal transcription factor-1.Checking the pH-induced conformational transition of prion protein by molecular dynamics simulations: effect of protonation of histidine residues.Modeling the interplay of glycine protonation and multiple histidine binding of copper in the prion protein octarepeat subdomains.Aberrant metal binding by prion protein in human prion disease.Acidic pH and detergents enhance in vitro conversion of human brain PrPC to a PrPSc-like form.Copper binding to the octarepeats of the prion protein. Affinity, specificity, folding, and cooperativity: insights from circular dichroism.Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced Neurodegeneration.Inter- and intra-octarepeat Cu(II) site geometries in the prion protein: implications in Cu(II) binding cooperativity and Cu(II)-mediated assemblies.Copper-induced conformational change in a marsupial prion protein repeat peptide probed using FTIR spectroscopy.High affinity binding between copper and full-length prion protein identified by two different techniques.Ionic strength and transition metals control PrPSc protease resistance and conversion-inducing activity.
P2860
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P2860
Electron paramagnetic resonance evidence for binding of Cu(2+) to the C-terminal domain of the murine prion protein
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Electron paramagnetic resonanc ...... in of the murine prion protein
@ast
Electron paramagnetic resonanc ...... in of the murine prion protein
@en
Electron paramagnetic resonanc ...... in of the murine prion protein
@nl
type
label
Electron paramagnetic resonanc ...... in of the murine prion protein
@ast
Electron paramagnetic resonanc ...... in of the murine prion protein
@en
Electron paramagnetic resonanc ...... in of the murine prion protein
@nl
prefLabel
Electron paramagnetic resonanc ...... in of the murine prion protein
@ast
Electron paramagnetic resonanc ...... in of the murine prion protein
@en
Electron paramagnetic resonanc ...... in of the murine prion protein
@nl
P2093
P2860
P1433
P1476
Electron paramagnetic resonanc ...... in of the murine prion protein
@en
P2093
Cereghetti GM
Glockshuber R
Schweiger A
Van Doorslaer S
P2860
P304
P356
10.1016/S0006-3495(01)75718-9
P407
P577
2001-07-01T00:00:00Z