Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases
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SU6656, a selective src family kinase inhibitor, used to probe growth factor signalingThe selectivity of protein kinase inhibitors: a further updateDiscovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndromeA new synthetic FGF receptor antagonist inhibits arteriosclerosis in a mouse vein graft model and atherosclerosis in apolipoprotein E-deficient miceCharacterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2Benchmarking sets for molecular dockingAntidepressant effects of fibroblast growth factor-2 in behavioral and cellular models of depressionInner ear hair cell-like cells from human embryonic stem cells.Leading and trailing cells cooperate in collective migration of the zebrafish posterior lateral line primordiumInhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.The development of zebrafish tendon and ligament progenitors.A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion.Use of kinase inhibitors to correct ΔF508-CFTR function.Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors.Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration.VEGF blocking therapy in the treatment of cancer.Mild and General Access to Diverse 1H-Benzotriazoles via Diboron-Mediated N-OH Deoxygenation and Palladium-Catalyzed C-C and C-N Bond FormationColon cancer angiogenesis and antiangiogenic therapy.Combinatorial Pharmacophore-Based 3D-QSAR Analysis and Virtual Screening of FGFR1 Inhibitors.FGF1 Mediates Overnutrition-Induced Compensatory β-Cell DifferentiationSox3 expression is maintained by FGF signaling and restricted to the neural plate by Vent proteins in the Xenopus embryoIntermolecularly Hydrogen-Bonded Dimeric Helices. Tripyrrindiones.In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration.Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8The immunopharmacologic potential of Semaxanib and new generation directed therapeutic drugs: Receptor tyrosine kinase regulation with anti-tumorigenensis/angiogenesis properties.Asynchronous fate decisions by single cells collectively ensure consistent lineage composition in the mouse blastocyst.Kinase inhibitors as potential agents in the treatment of multiple myeloma.Oxindole-based SYK and JAK3 dual inhibitors for rheumatoid arthritis: designing, synthesis and biological evaluation.Multi-kinase inhibitors, AURKs and cancer.Computer-aided discovery of new FGFR-1 inhibitors followed by in vitro validation.Preclinical anti-angiogenesis and anti-tumor activity of SIM010603, an oral, multi-targets receptor tyrosine kinases inhibitor.IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.Snail promotes the cell-autonomous generation of Flk1(+) endothelial cells through the repression of the microRNA-200 family.Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives.Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells.p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development.Neural crest cells pattern the surface cephalic ectoderm during FEZ formation.Endothelin-1 decreases endothelial PPARγ signaling and impairs angiogenesis after chronic intrauterine pulmonary hypertension.FGF signaling is required for lens regeneration in Xenopus laevis.Fibroblast growth factor rescues brain endothelial cells lacking presenilin 1 from apoptotic cell death following serum starvation.
P2860
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P2860
Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Design, synthesis, and evaluat ...... PDGF receptor tyrosine kinases
@ast
Design, synthesis, and evaluat ...... PDGF receptor tyrosine kinases
@en
Design, synthesis, and evaluat ...... PDGF receptor tyrosine kinases
@nl
type
label
Design, synthesis, and evaluat ...... PDGF receptor tyrosine kinases
@ast
Design, synthesis, and evaluat ...... PDGF receptor tyrosine kinases
@en
Design, synthesis, and evaluat ...... PDGF receptor tyrosine kinases
@nl
prefLabel
Design, synthesis, and evaluat ...... PDGF receptor tyrosine kinases
@ast
Design, synthesis, and evaluat ...... PDGF receptor tyrosine kinases
@en
Design, synthesis, and evaluat ...... PDGF receptor tyrosine kinases
@nl
P2093
P3181
P356
P1476
Design, synthesis, and evaluat ...... PDGF receptor tyrosine kinases
@en
P2093
L K Shawver
P304
P3181
P356
10.1021/JM9904295
P407
P577
1999-12-16T00:00:00Z