Cardiac sodium channels (hH1) are intrinsically more sensitive to block by lidocaine than are skeletal muscle (mu 1) channels
about
Anaesthetic tricaine acts preferentially on neural voltage-gated sodium channels and fails to block directly evoked muscle contractionChannel cytoplasmic loops alter voltage-dependent sodium channel activation in an isoform-specific mannerCommon molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channelsComparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and LidocaineImproving cardiac conduction with a skeletal muscle sodium channel by gene and cell therapyDiversity of mammalian voltage-gated sodium channels.Potent and use-dependent block of cardiac sodium channels by U-50,488H, a benzeneacetamide kappa opioid receptor agonist.Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior.Differences in steady-state inactivation between Na channel isoforms affect local anesthetic binding affinity.Isoform-specific lidocaine block of sodium channels explained by differences in gatingState-dependent cocaine block of sodium channel isoforms, chimeras, and channels coexpressed with the beta1 subunit.Functional consequences of lidocaine binding to slow-inactivated sodium channelsThe position of the fast-inactivation gate during lidocaine block of voltage-gated Na+ channelsLocal anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels.Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels.Gating of skeletal and cardiac muscle sodium channels in mammalian cells.Ligand-insensitive state of cardiac ATP-sensitive K+ channels. Basis for channel opening.The selectivity filter of the voltage-gated sodium channel is involved in channel activation.Isoform-specific effects of sialic acid on voltage-dependent Na+ channel gating: functional sialic acids are localized to the S5-S6 loop of domain I.Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block.Modulation of neuronal activity by the endogenous pentapeptide QYNAD.Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Nav 1.1 to Nav 1.7).
P2860
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P2860
Cardiac sodium channels (hH1) are intrinsically more sensitive to block by lidocaine than are skeletal muscle (mu 1) channels
description
1995 nî lūn-bûn
@nan
1995 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Cardiac sodium channels (hH1) ...... keletal muscle (mu 1) channels
@ast
Cardiac sodium channels (hH1) ...... keletal muscle (mu 1) channels
@en
Cardiac sodium channels (hH1) ...... keletal muscle (mu 1) channels
@nl
type
label
Cardiac sodium channels (hH1) ...... keletal muscle (mu 1) channels
@ast
Cardiac sodium channels (hH1) ...... keletal muscle (mu 1) channels
@en
Cardiac sodium channels (hH1) ...... keletal muscle (mu 1) channels
@nl
prefLabel
Cardiac sodium channels (hH1) ...... keletal muscle (mu 1) channels
@ast
Cardiac sodium channels (hH1) ...... keletal muscle (mu 1) channels
@en
Cardiac sodium channels (hH1) ...... keletal muscle (mu 1) channels
@nl
P2093
P356
P1476
Cardiac sodium channels (hH1) ...... keletal muscle (mu 1) channels
@en
P2093
P304
P356
10.1085/JGP.106.6.1193
P407
P577
1995-12-01T00:00:00Z