Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils
about
Pauling and Corey's alpha-pleated sheet structure may define the prefibrillar amyloidogenic intermediate in amyloid diseaseExpression and purification of 15N- and 13C-isotope labeled 40-residue human Alzheimer's β-amyloid peptide for NMR-based structural analysisAmyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structureAmyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structureElectrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomicsHigh-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopyTowards a Pharmacophore for AmyloidMolecular basis for amyloid- polymorphismAntiparallel -sheet architecture in Iowa-mutant -amyloid fibrilsAtomic Resolution Structure of Monomorphic Aβ42 Amyloid FibrilsMolecular Structure of Aggregated Amyloid-β: Insights from Solid-State Nuclear Magnetic ResonanceNeuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer diseaseSupramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance.Site-specific identification of non-beta-strand conformations in Alzheimer's beta-amyloid fibrils by solid-state NMRA structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMRExperimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrilsSolid-state NMR as a probe of amyloid structureCharacterization of amyloid structures at the molecular level by solid state nuclear magnetic resonance spectroscopySpontaneous fibril formation by polyalanines; discontinuous molecular dynamics simulationsA model for Ure2p prion filaments and other amyloids: the parallel superpleated beta-structureA multiscale approach to characterize the early aggregation steps of the amyloid-forming peptide GNNQQNY from the yeast prion sup-35Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR StudyIntermolecular structure determination of amyloid fibrils with magic-angle spinning and dynamic nuclear polarization NMR.An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.Effect of the amyloid β hairpin's structure on the handedness of helices formed by its aggregates.Parallel in-register intermolecular β-sheet architectures for prion-seeded prion protein (PrP) amyloids.Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFMDesign and characterization of a membrane permeable N-methyl amino acid-containing peptide that inhibits Abeta1-40 fibrillogenesis.Increasing the amphiphilicity of an amyloidogenic peptide changes the beta-sheet structure in the fibrils from antiparallel to parallelPolymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide.Parallel beta-sheets and polar zippers in amyloid fibrils formed by residues 10-39 of the yeast prion protein Ure2p.Metal ion-dependent, reversible, protein filament formation by designed beta-roll polypeptides.Effect of metals on kinetic pathways of amyloid-β aggregationConformational switching in PolyGln amyloid fibrils resulting from a single amino acid insertion.Beta arcades: recurring motifs in naturally occurring and disease-related amyloid fibrilsAmyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Characterization of a possible amyloidogenic precursor in glutamine-repeat neurodegenerative diseases.Structural studies of the scrapie prion protein by electron crystallography.Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils.Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape.
P2860
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P2860
Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils
description
2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
@zh-hk
2000年論文
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Multiple quantum solid-state N ...... zheimer's beta-amyloid fibrils
@ast
Multiple quantum solid-state N ...... zheimer's beta-amyloid fibrils
@en
Multiple quantum solid-state N ...... zheimer's beta-amyloid fibrils
@nl
type
label
Multiple quantum solid-state N ...... zheimer's beta-amyloid fibrils
@ast
Multiple quantum solid-state N ...... zheimer's beta-amyloid fibrils
@en
Multiple quantum solid-state N ...... zheimer's beta-amyloid fibrils
@nl
prefLabel
Multiple quantum solid-state N ...... zheimer's beta-amyloid fibrils
@ast
Multiple quantum solid-state N ...... zheimer's beta-amyloid fibrils
@en
Multiple quantum solid-state N ...... zheimer's beta-amyloid fibrils
@nl
P2093
P2860
P356
P1476
Multiple quantum solid-state N ...... zheimer's beta-amyloid fibrils
@en
P2093
P2860
P304
P356
10.1073/PNAS.230315097
P407
P577
2000-11-21T00:00:00Z