Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms
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Roles of transforming growth factor-β1 and OB-cadherin in porcine cardiac valve myofibroblast differentiation.Anti-fibrogenic effect of PPAR-γ agonists in human intestinal myofibroblasts.Aging impairs VEGF-mediated, androgen-dependent regulation of angiogenesisThe T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression.Genetic variants in PI3K/AKT pathway are associated with severe radiation pneumonitis in lung cancer patients treated with radiation therapyIdentification of sirtuin 1 as a promising therapeutic target for hypertrophic scars.Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPFHydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway.Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort studyToll-interacting protein (Tollip) negatively regulates pressure overload-induced ventricular hypertrophy in miceSaponins from the roots of Platycodon grandiflorum suppresses TGFβ1-induced epithelial-mesenchymal transition via repression of PI3K/Akt, ERK1/2 and Smad2/3 pathway in human lung carcinoma A549 cells.Inhibition of TRPM7 channels prevents proliferation and differentiation of human lung fibroblasts.Lung carcinogenesis and fibrosis taken together: just coincidence?Thymosin β4 protects C57BL/6 mice from bleomycin-induced damage in the lung.Schistosoma japonicum egg antigen up-regulates fibrogenesis and inhibits proliferation in primary hepatic stellate cells in a concentration-dependent manner.Targeting of Discoidin Domain Receptor 2 (DDR2) Prevents Myofibroblast Activation and Neovessel Formation During Pulmonary Fibrosis.Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter.Getting out of a sticky situation: targeting the myofibroblast in sclerodermaHS-173, a novel PI3K inhibitor, attenuates the activation of hepatic stellate cells in liver fibrosisPI3K p110γ overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast cells: in vitro effects of its inhibition."Scar-cinoma": viewing the fibrotic lung mesenchymal cell in the context of cancer biology.Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway.Evaluation of WO2013117503 and WO2013117504: the use of PI3K inhibitors to treat cough or idiopathic pulmonary fibrosis.The Tension Biology of Wound Healing.CCN5/WISP2 and metabolic diseases.AKT2 Regulates Pulmonary Inflammation and Fibrosis via Modulating Macrophage Activation.Are newly launched pharmacotherapies efficacious in treating idiopathic pulmonary fibrosis? Or is there still more work to be done?FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis.Repositioning compounds from cancer drug discovery to IPF: PI3K inhibition.Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway.Acute downregulation of miR-155 leads to a reduced collagen synthesis through attenuating macrophages inflammatory factor secretion by targeting SHIP1.Mechanosensitive transient receptor potential vanilloid 4 regulates Dermatophagoides farinae-induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation.The correlation between miR-200c and the severity of interstitial lung disease associated with different connective tissue diseases.The positive role of vitronectin in radiation induced lung toxicity: the in vitro and in vivo mechanism study.FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis.Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt.
P2860
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P2860
Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms
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2011 nî lūn-bûn
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2011 թուականին հրատարակուած գիտական յօդուած
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2011 թվականին հրատարակված գիտական հոդված
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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name
Inhibition of PI3K prevents th ...... role of class I P110 isoforms
@ast
Inhibition of PI3K prevents th ...... role of class I P110 isoforms
@en
Inhibition of PI3K prevents th ...... role of class I P110 isoforms
@nl
type
label
Inhibition of PI3K prevents th ...... role of class I P110 isoforms
@ast
Inhibition of PI3K prevents th ...... role of class I P110 isoforms
@en
Inhibition of PI3K prevents th ...... role of class I P110 isoforms
@nl
prefLabel
Inhibition of PI3K prevents th ...... role of class I P110 isoforms
@ast
Inhibition of PI3K prevents th ...... role of class I P110 isoforms
@en
Inhibition of PI3K prevents th ...... role of class I P110 isoforms
@nl
P2093
P2860
P50
P3181
P1433
P1476
Inhibition of PI3K prevents th ...... role of class I P110 isoforms
@en
P2093
Elisa Gili
Enrico Conte
Evelina Fagone
Maria Iemmolo
Mary Fruciano
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0024663
P407
P577
2011-10-03T00:00:00Z