about
Sirtuin functions in health and diseaseProgesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferationPancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas developmentActivation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation.Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cellsStructure-based design of a superagonist ligand for the vitamin D nuclear receptorThe small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activityAdipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gammaBile acids induce energy expenditure by promoting intracellular thyroid hormone activationRole of peroxisome proliferator-activated receptor alpha in epidermal development in uteroLiver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammationNR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo.Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traitsPharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle.Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading.Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.Liver receptor homolog 1 controls the expression of carboxyl ester lipase.NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis.The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.Bile acid binding resin improves metabolic control through the induction of energy expenditureIntestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistanceNAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice.Liver receptor homolog 1 is essential for ovulation.The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.The bile acid membrane receptor TGR5: a valuable metabolic target.Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure.TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translationThe metabolic footprint of aging in miceLRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis.TGR5 potentiates GLP-1 secretion in response to anionic exchange resins.LRH-1-dependent glucose sensing determines intermediary metabolism in liver.Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors.Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice.Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Kristina Schoonjans
@ast
Kristina Schoonjans
@en
Kristina Schoonjans
@es
Kristina Schoonjans
@nl
Kristina Schoonjans
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type
label
Kristina Schoonjans
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Kristina Schoonjans
@en
Kristina Schoonjans
@es
Kristina Schoonjans
@nl
Kristina Schoonjans
@sl
prefLabel
Kristina Schoonjans
@ast
Kristina Schoonjans
@en
Kristina Schoonjans
@es
Kristina Schoonjans
@nl
Kristina Schoonjans
@sl