Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor
about
Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal modelsA blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD)Evaluation of traditional medicines for neurodegenerative diseases using Drosophila modelsCharacteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet MimicsFlexibility and binding affinity in protein-ligand, protein-protein and multi-component protein interactions: limitations of current computational approaches.Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Development and validation of a yeast high-throughput screen for inhibitors of Aβ₄₂ oligomerization.Structure-activity relationships for a series of compounds that inhibit aggregation of the Alzheimer's peptide, Aβ42A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease.Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry.Mutations that replace aromatic side chains promote aggregation of the Alzheimer's Aβ peptide.Carbon nanotube inhibits the formation of β-sheet-rich oligomers of the Alzheimer's amyloid-β(16-22) peptide.The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systemsESI-IMS-MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules.Disordered binding of small molecules to Aβ(12-28).Adsorption mechanism and collapse propensities of the full-length, monomeric Aβ(1-42) on the surface of a single-walled carbon nanotube: a molecular dynamics simulation study.A novel, sensitive assay for behavioral defects in Parkinson's disease model DrosophilaA novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease.Evaluating Drosophila p53 as a model system for studying cancer mutationsConvergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.Monitoring and targeting the initial dimerization stage of amyloid self-assembly.Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer's disease.The flavonoid derivative 2-(4' Benzyloxyphenyl)-3-hydroxy-chromen-4-one protects against Aβ42-induced neurodegeneration in transgenic Drosophila: insights from in silico and in vivo studies.Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease.Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp.Role of aromatic side chains in amyloid β-protein aggregation.Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity.The inhibitory mechanism of a fullerene derivative against amyloid-β peptide aggregation: an atomistic simulation study.Atomic-resolution map of the interactions between an amyloid inhibitor protein and amyloid β (Aβ) peptides in the monomer and protofibril states.Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide.Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database.Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity.Investigation of naphthofuran moiety as potential dual inhibitor against BACE-1 and GSK-3β: molecular dynamics simulations, binding energy, and network analysis to identify first-in-class dual inhibitors against Alzheimer's disease.Rosmarinic Acid Restores Complete Transparency of Sonicated Human Cataract Ex Vivo and Delays Cataract Formation In Vivo.Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms
P2860
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P2860
Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Complete phenotypic recovery o ...... n hybrid aggregation inhibitor
@ast
Complete phenotypic recovery o ...... n hybrid aggregation inhibitor
@en
Complete phenotypic recovery o ...... n hybrid aggregation inhibitor
@nl
type
label
Complete phenotypic recovery o ...... n hybrid aggregation inhibitor
@ast
Complete phenotypic recovery o ...... n hybrid aggregation inhibitor
@en
Complete phenotypic recovery o ...... n hybrid aggregation inhibitor
@nl
prefLabel
Complete phenotypic recovery o ...... n hybrid aggregation inhibitor
@ast
Complete phenotypic recovery o ...... n hybrid aggregation inhibitor
@en
Complete phenotypic recovery o ...... n hybrid aggregation inhibitor
@nl
P2093
P2860
P1433
P1476
Complete phenotypic recovery o ...... n hybrid aggregation inhibitor
@en
P2093
Amedeo Caflisch
Anat Frydman-Marom
Daniel Segal
Deborah E Shalev
Ehud Gazit
Marino Convertino
Michal Levy-Sakin
Nirit Egoz-Matia
Riccardo Pellarin
Roni Scherzer-Attali
P2860
P304
P356
10.1371/JOURNAL.PONE.0011101
P407
P577
2010-06-14T00:00:00Z