Conformational changes and slow dynamics through microsecond polarized atomistic molecular simulation of an integral Kv1.2 ion channel
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Voltage-Controlled Enzymes: The New JanusBifronsOne-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologueShifting hydrogen bonds may produce flexible transmembrane helices.Shock Wave-Induced Damage of a Protein by Void CollapseModeling and simulation of ion channels.From the gating charge response to pore domain movement: initial motions of Kv1.2 dynamics under physiological voltage changes.The sliding-helix voltage sensor: mesoscale views of a robust structure-function relationship.An efficient and extensible format, library, and API for binary trajectory data from molecular simulations.Electrostatic tuning of cellular excitability.Calculation of the gating charge for the Kv1.2 voltage-activated potassium channelDown-state model of the voltage-sensing domain of a potassium channel.Meet me on the other side: trans-bilayer modulation of a model voltage-gated ion channel activity by membrane electrostatics asymmetry3(10) helices in channels and other membrane proteinsMolecular dynamics-based approaches for enhanced sampling of long-time, large-scale conformational changes in biomolecules.In search of a consensus model of the resting state of a voltage-sensing domainDomain and interdomain energetics underlying gating in Shaker-type Kv channelsThe free energy barrier for arginine gating charge translation is altered by mutations in the voltage sensor domain.Capturing distinct KCNQ2 channel resting states by metal ion bridges in the voltage-sensor domain.3₁₀-helix conformation facilitates the transition of a voltage sensor S4 segment toward the down state.Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations.Control of a final gating charge transition by a hydrophobic residue in the S2 segment of a K+ channel voltage sensor.Molecular dynamics investigation of the ω-current in the Kv1.2 voltage sensor domains.Derivation and systematic validation of a refined all-atom force field for phosphatidylcholine lipidsComputer Simulations of Voltage-Gated Cation ChannelsMolecular dynamics simulations of voltage-gated cation channels: insights on voltage-sensor domain function and modulation.A limited 4 Å radial displacement of the S4-S5 linker is sufficient for internal gate closing in Kv channels.An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulationsThe cytosolic GH loop regulates the phosphatidylinositol 4,5-bisphosphate-induced gating kinetics of Kir2 channels.The conserved phenylalanine in the K+ channel voltage-sensor domain creates a barrier with unidirectional effects.The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel.Evolutionary imprint of activation: the design principles of VSDs.Lipid simulations: a perspective on lipids in action.Mechanism of electromechanical coupling in voltage-gated potassium channels.Mechanisms of activation of voltage-gated potassium channels.Dewetting transition assisted clearance of (NFGAILS) amyloid fibrils from cell membranes by graphene.An electrostatic potassium channel opener targeting the final voltage sensor transition.Voltage-dependent conformational changes of KVAP S4 segment in bacterial membrane environment.Independent and cooperative motions of the Kv1.2 channel: voltage sensing and gating.Conformational dynamics of shaker-type Kv1.1 ion channel in open, closed, and two mutated states.
P2860
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P2860
Conformational changes and slow dynamics through microsecond polarized atomistic molecular simulation of an integral Kv1.2 ion channel
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Conformational changes and slo ...... an integral Kv1.2 ion channel
@ast
Conformational changes and slo ...... an integral Kv1.2 ion channel
@en
Conformational changes and slo ...... an integral Kv1.2 ion channel
@nl
type
label
Conformational changes and slo ...... an integral Kv1.2 ion channel
@ast
Conformational changes and slo ...... an integral Kv1.2 ion channel
@en
Conformational changes and slo ...... an integral Kv1.2 ion channel
@nl
prefLabel
Conformational changes and slo ...... an integral Kv1.2 ion channel
@ast
Conformational changes and slo ...... an integral Kv1.2 ion channel
@en
Conformational changes and slo ...... an integral Kv1.2 ion channel
@nl
P2860
P3181
P1476
Conformational changes and slo ...... an integral Kv1.2 ion channel
@en
P2093
Ilpo Vattulainen
Perttu S Niemelä
P2860
P304
P3181
P356
10.1371/JOURNAL.PCBI.1000289
P407
P577
2009-02-01T00:00:00Z