Mechanism of microRNA-target interaction: molecular dynamics simulations and thermodynamics analysis
about
A structural view of microRNA-target recognitionMicroRNA expression and regulation in human ovarian carcinoma cells by luteinizing hormone.Large domain motions in Ago protein controlled by the guide DNA-strand seed region determine the Ago-DNA-mRNA complex recognition processDynamic mechanisms for pre-miRNA binding and export by Exportin-5.In silico identification of structure requirement for novel thiazole and oxazole derivatives as potent fructose 1,6-bisphosphatase inhibitors.Structural requirements of N-substituted spiropiperidine analogues as agonists of nociceptin/orphanin FQ receptorMarkov State Models Reveal a Two-Step Mechanism of miRNA Loading into the Human Argonaute Protein: Selective Binding followed by Structural Re-arrangement.Elucidation of the Molecular Interaction between miRNAs and the HOXA9 Gene, Involved in Acute Myeloid Leukemia, by the Assistance of Argonaute Protein through a Computational ApproachIdentification of novel potential β-N-acetyl-D-hexosaminidase inhibitors by virtual screening, molecular dynamics simulation and MM-PBSA calculations.Assembly and analysis of eukaryotic Argonaute-RNA complexes in microRNA-target recognition.Maternal slaughter at abattoirs: history, causes, cases and the meat industry.Structural Dynamics of Human Argonaute2 and Its Interaction with siRNAs Designed to Target Mutant tdp43.In Silico Study of miRNA Based Gene Regulation, Involved in Solid Cancer, by the Assistance of Argonaute Protein.NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo.Frontiers in preclinical safety biomarkers: microRNAs and messenger RNAs.Atomistic-level portrayal of drug-DNA Interplay: a history of courtships and meetings revealed by molecular simulations.Identifying mRNA sequence elements for target recognition by human Argonaute proteins.Modeling and analysis of Schistosoma Argonaute protein molecular spatial conformation.Molecular simulation of a series of benzothiazole PI3Kα inhibitors: probing the relationship between structural features, anti-tumor potency and selectivity.Functional and Genetic Analysis Identify a Role for Arabidopsis ARGONAUTE5 in Antiviral RNA Silencing.Tertiary structure-based analysis of microRNA-target interactions.Thermodynamic basis of selectivity in guide-target-mismatched RNA interference.Studies of new fused benzazepine as selective dopamine D3 receptor antagonists using 3D-QSAR, molecular docking and molecular dynamicsCustomization of Artificial MicroRNA Design.Exploring the RNA-bound and RNA-free human Argonaute-2 by molecular dynamics simulation method.Elucidating Mechanisms of Molecular Recognition Between Human Argonaute and miRNA Using Computational Approaches.Local and global effects of Mg2+ on Ago and miRNA-target interactions.A molecular dynamics study of a miRNA:mRNA interaction.Structural and binding study of modified siRNAs with the Argonaute 2 PAZ domain by NMR spectroscopy.Understanding the molecular basis of MK2-p38α signaling complex assembly: insights into protein-protein interaction by molecular dynamics and free energy studies.Exploring PAZ/3'-overhang interaction to improve siRNA specificity. A combined experimental and modeling study.Why Is a High Temperature Needed by Thermus thermophilus Argonaute During mRNA Silencing: A Theoretical Study.
P2860
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P2860
Mechanism of microRNA-target interaction: molecular dynamics simulations and thermodynamics analysis
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Mechanism of microRNA-target i ...... ns and thermodynamics analysis
@ast
Mechanism of microRNA-target i ...... ns and thermodynamics analysis
@en
Mechanism of microRNA-target i ...... ns and thermodynamics analysis
@nl
type
label
Mechanism of microRNA-target i ...... ns and thermodynamics analysis
@ast
Mechanism of microRNA-target i ...... ns and thermodynamics analysis
@en
Mechanism of microRNA-target i ...... ns and thermodynamics analysis
@nl
prefLabel
Mechanism of microRNA-target i ...... ns and thermodynamics analysis
@ast
Mechanism of microRNA-target i ...... ns and thermodynamics analysis
@en
Mechanism of microRNA-target i ...... ns and thermodynamics analysis
@nl
P2093
P2860
P3181
P1476
Mechanism of microRNA-target i ...... ns and thermodynamics analysis
@en
P2093
P2860
P304
P3181
P356
10.1371/JOURNAL.PCBI.1000866
P407
P577
2010-07-29T00:00:00Z