PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90 - Wikidata - wikimedia - TriplyDB

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90

http://www.wikidata.org/entity/Q28475333

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Role of Heat-Shock Proteins in Cellular Function and in the Biology of Fungi pH signaling in human fungal pathogens: a new target for antifungal strategies Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans Hsp90 governs dispersion and drug resistance of fungal biofilms Calcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicans Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations Hsp21 potentiates antifungal drug tolerance in Candida albicans Fitness trade-offs restrict the evolution of resistance to amphotericin B Functional Divergence of Hsp90 Genetic Interactions in Biofilm and Planktonic Cellular States Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular Stress Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis Selective BET bromodomain inhibition as an antifungal therapeutic strategy Highly Dynamic and Specific Phosphatidylinositol 4,5-Bisphosphate, Septin, and Cell Wall Integrity Pathway Responses Correlate with Caspofungin Activity against Candida albicans.Mechanisms of Candida albicans trafficking to the brain.Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints.Synergistic Activity of Econazole-Nitrate and Chelerythrine against Clinical Isolates of Candida albicans Regulatory circuitry governing fungal development, drug resistance, and disease.Elucidating drug resistance in human fungal pathogens.Hsp90 is involved in apoptosis of Candida albicans by regulating the calcineurin-caspase apoptotic pathway.Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast.G1/S transcription factor orthologues Swi4p and Swi6p are important but not essential for cell proliferation and influence hyphal development in the fungal pathogen Candida albicans.Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules Sur7 promotes plasma membrane organization and is needed for resistance to stressful conditions and to the invasive growth and virulence of Candida albicans.Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo.The Mkk2 MAPKK Regulates Cell Wall Biogenesis in Cooperation with the Cek1-Pathway in Candida albicans.The Aspergillus fumigatus pkcA G579R Mutant Is Defective in the Activation of the Cell Wall Integrity Pathway but Is Dispensable for Virulence in a Neutropenic Mouse Infection Model.Targeting the oxidative stress response system of fungi with redox-potent chemosensitizing agents.Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans.Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues.An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens The non-Geldanamycin Hsp90 inhibitors enhanced the antifungal activity of fluconazole.Molecular Characterization of Gβ-Like Protein CpcB Involved in Antifungal Drug Susceptibility and Virulence in A. fumigatus Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis Surface stress induces a conserved cell wall stress response in the pathogenic fungus Candida albicans.Candida albicans pathogenicity mechanisms.

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P2860

PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90

http://www.wikidata.org/entity/Q28475333

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90

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PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90

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PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90

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type

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PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90

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PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90

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PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90

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PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90

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PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90

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PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90

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PKC signaling regulates drug r ...... f Mkc1, calcineurin, and Hsp90

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A A Leslie Gunatilaka

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Aimee K Zaas

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Cathy Collins

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Marisol Betancourt-Quiroz

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Shantelle L LaFayette

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Wiley A Schell

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P2860

Animals and fungi are each other's closest relatives: congruent evidence from multiple proteins

Bacterial small-molecule signaling pathways

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone.

A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p).

Genetic architecture of Hsp90-dependent drug resistance.

Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation

Saccharomyces cerevisiae PKC1 encodes a protein kinase C (PKC) homolog with a substrate specificity similar to that of mammalian PKC.

The pleitropic drug ABC transporters from Saccharomyces cerevisiae.

A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization

Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence

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