Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest
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Nuclear assembly as a target for anti-cancer therapiesThe 3' untranslated region of the cyclin B mRNA is not sufficient to enhance the synthesis of cyclin B during a mitotic block in human cellsQuantifying intrinsic and extrinsic control of single-cell fates in cancer and stem/progenitor cell pedigrees with competing risks analysisTemporal competition between differentiation programs determines cell fate choice.The spindle assembly checkpoint works like a rheostat rather than a toggle switchThe NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrestLongitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor.Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.Measuring and modeling apoptosis in single cells.Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL.Caspase activity is not required for the mitotic checkpoint or mitotic slippage in human cells.Inhibition of Bcl-xL overcomes polyploidy resistance and leads to apoptotic cell death in acute myeloid leukemia cells.MYC Is a Major Determinant of Mitotic Cell Fate.Cell death detection by quantitative three-dimensional single-cell tomography.Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins.Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinasesA simplified Bcl-2 network model reveals quantitative determinants of cell-to-cell variation in sensitivity to anti-mitotic chemotherapeutics.Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules.Phosphatases: providing safe passage through mitotic exit.Event timing at the single-cell level.Dual recognition of chromatin and microtubules by INCENP is important for mitotic progression.Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinicTargeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair.Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest.Modeling Cancer Cell Growth Dynamics In vitro in Response to Antimitotic Drug TreatmentMcl-1 dynamics influence mitotic slippage and death in mitosis.Single cell transcriptional analysis reveals novel innate immune cell types.Genome-wide siRNA screen reveals coupling between mitotic apoptosis and adaptationThe complexity of life and death decisions in mitosis.Stop competing, start talking!Perturbing mitosis for anti-cancer therapy: is cell death the only answer?Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison.Universal response in the RKO colon cancer cell line to distinct antimitotic therapies.
P2860
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P2860
Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest
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2010 nî lūn-bûn
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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
@zh-mo
2010年論文
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2010年论文
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Stochastic competition between ...... ell fate during mitotic arrest
@ast
Stochastic competition between ...... ell fate during mitotic arrest
@en
Stochastic competition between ...... ell fate during mitotic arrest
@nl
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label
Stochastic competition between ...... ell fate during mitotic arrest
@ast
Stochastic competition between ...... ell fate during mitotic arrest
@en
Stochastic competition between ...... ell fate during mitotic arrest
@nl
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Stochastic competition between ...... ell fate during mitotic arrest
@ast
Stochastic competition between ...... ell fate during mitotic arrest
@en
Stochastic competition between ...... ell fate during mitotic arrest
@nl
P2860
P3181
P1433
P1476
Stochastic competition between ...... ell fate during mitotic arrest
@en
P2093
Hsiao-Chun Huang
Timothy J Mitchison
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0015724
P407
P50
P577
2010-12-21T00:00:00Z