SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus
about
Metabolic remodeling in iron-deficient fungiHypoxia and fungal pathogenesis: to air or not to air?Aspergillus fumigatus invasion increases with progressive airway ischemiaSterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding ComplexTranscriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species ComparisonThe immune interplay between the host and the pathogen in Aspergillus fumigatus lung infectionA Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B ExpressionsDiscovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossingThe fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatusZinc finger transcription factors displaced SREBP proteins as the major Sterol regulators during Saccharomycotina evolutionA novel sterol regulatory element-binding protein gene (sreA) identified in penicillium digitatum is required for prochloraz resistance, full virulence and erg11 (cyp51) regulationChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulenceGenetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus's Role in VirulenceCharacterization of the Paracoccidioides Hypoxia Response Reveals New Insights into Pathogenesis Mechanisms of This Important Human Pathogenic FungusSuppressing Farnesyl Diphosphate Synthase Alters Chloroplast Development and Triggers Sterol-Dependent Induction of Jasmonate- and Fe-Related ResponsesFilamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression.Functional analysis of two sterol regulatory element binding proteins in Penicillium digitatumRegulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approachTranscriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter.Fungal siderophore metabolism with a focus on Aspergillus fumigatus.Transcriptional and proteomic analysis of the Aspergillus fumigatus ΔprtT protease-deficient mutant.Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus.Elucidating drug resistance in human fungal pathogens.Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus.The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess.Large-scale transcriptional response to hypoxia in Aspergillus fumigatus observed using RNAseq identifies a novel hypoxia regulated ncRNA.Characterization of the Link between Ornithine, Arginine, Polyamine and Siderophore Metabolism in Aspergillus fumigatus.Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus.SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).Genome-Wide Analysis of Hypoxia-Responsive Genes in the Rice Blast Fungus, Magnaporthe oryzae.Iron - A Key Nexus in the Virulence of Aspergillus fumigatus.RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behaviorAspergillus fumigatus mitochondrial electron transport chain mediates oxidative stress homeostasis, hypoxia responses and fungal pathogenesis.HapX Mediates Iron Homeostasis in the Pathogenic Dermatophyte Arthroderma benhamiae but Is Dispensable for Virulence.Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence.Protein kinase A and fungal virulence: a sinister side to a conserved nutrient sensing pathway.The quinoline bromoquinol exhibits broad-spectrum antifungal activity and induces oxidative stress and apoptosis in Aspergillus fumigatus.Coordination of hypoxia adaptation and iron homeostasis in human pathogenic fungi.De-repression of CSP-1 activates adaptive responses to antifungal azoles.Dsc orthologs are required for hypoxia adaptation, triazole drug responses, and fungal virulence in Aspergillus fumigatus.
P2860
Q26858881-C0831B6D-CC12-4699-8416-2C1DB6ABA3D3Q27023320-9045E28A-BBC6-45B7-90E1-90F440E6CD03Q27304352-EB8FBCA9-0C4E-4DB0-9E0A-EB3C5C54C957Q27312432-3E567190-3A92-4753-84D9-9991A6DBE151Q28079641-0E3D93F9-7651-468B-A1FA-E12A28A5A377Q28387394-C1385E30-51CA-4DB4-958D-7FCD16EC1E5EQ28468399-F1FE1BFF-33BA-4624-8E9F-6628DA80A5D9Q28485433-82E8C967-35F0-42CB-8586-6E2146410DABQ28534135-DCB01687-880C-4A8A-8A32-58CAA1F59BB0Q28538769-B91662EA-A7B7-4607-9009-EE5232CC1836Q28543563-D258FD76-707D-4984-9918-767FFA91E95AQ28544794-73FF2FA1-BF26-4CE4-B8DF-83F14E6B4A36Q28546712-BACB934C-FA7E-416D-B3BF-4A0303123528Q28551656-48F53F18-FCF9-4713-B098-A2CF954B9404Q28821360-E03DBBA1-F296-4CA9-A222-70098D0B5304Q33621006-26D7735B-76CF-4772-A068-C3633F77F38AQ33632720-22887802-BFC2-4552-8648-F00DB456357FQ34133098-F527CF4C-B826-40AC-B5C2-FFE4618CA90FQ34151913-5B96B879-D269-4CBB-BFF8-AD10D81A64CFQ34172089-B61DA14D-459F-433A-810F-BD11BA9981E2Q34238420-0634708D-1FF9-494C-B547-5784C216B187Q34399134-4241C54E-BE69-4ED6-8482-23717324546DQ34419351-921F9D73-F9EE-404C-95DD-840B02331910Q34447311-47ADAFBD-17B2-44B7-B2B5-67F9A27E6059Q34511507-241B0053-CDDD-48C0-AA96-7A6E70FE54BEQ34550626-F4412A4E-4DB1-4716-A51F-3A7F1C2A2EDFQ34794950-2566F7E8-09FD-4422-B464-DC94CF1D67E8Q35587757-7A157C41-8BC1-434E-BE84-41DD71E0A35BQ35666510-1BBBE2CB-70FF-4D24-8B90-964D2E845605Q35737591-E2BEE70E-2890-45F5-AED7-8F97E8A2A1B9Q35738573-2907F7CA-2134-4B80-ACE3-962645A3C29AQ35756850-DD78C982-33CE-4C33-B411-E564D1EA3327Q35881747-68C2E8FF-23BD-4E80-9596-1CEF433BF49FQ35951401-FD8A2E5A-2BCA-4523-92A6-B54F067E561FQ35986516-90CE0FB1-AA0F-440A-A73C-969173F6E7C0Q36094745-44D3956A-3D27-4D0C-81F2-00FC971EF69BQ36364366-628022C2-68D5-4BD2-8D8D-8F90056518F0Q36374709-DD887805-F851-4386-9D23-BBE23C9ABC7DQ36500088-0553C238-55D1-42BC-862D-0F9247692814Q36506539-6929A4FB-41BE-4977-B7A5-45EDEA1CAB74
P2860
SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
SREBP coordinates iron and erg ...... pathogen Aspergillus fumigatus
@ast
SREBP coordinates iron and erg ...... pathogen Aspergillus fumigatus
@en
SREBP coordinates iron and erg ...... pathogen Aspergillus fumigatus
@nl
type
label
SREBP coordinates iron and erg ...... pathogen Aspergillus fumigatus
@ast
SREBP coordinates iron and erg ...... pathogen Aspergillus fumigatus
@en
SREBP coordinates iron and erg ...... pathogen Aspergillus fumigatus
@nl
prefLabel
SREBP coordinates iron and erg ...... pathogen Aspergillus fumigatus
@ast
SREBP coordinates iron and erg ...... pathogen Aspergillus fumigatus
@en
SREBP coordinates iron and erg ...... pathogen Aspergillus fumigatus
@nl
P2093
P2860
P50
P921
P3181
P1433
P1476
SREBP coordinates iron and erg ...... pathogen Aspergillus fumigatus
@en
P2093
Elizabeth J Cornish
Hubertus Haas
Michael Blatzer
Nora Grahl
Robert A Cramer
Sara J Blosser
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1002374
P407
P577
2011-12-01T00:00:00Z