Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity - Wikidata - wikimedia - TriplyDB

Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity

Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity

http://www.wikidata.org/entity/Q28479009

about

Leptin signaling and leptin resistance Somato-dendritic localization and signaling by leptin receptors in hypothalamic POMC and AgRP neurons A mitochondrial-targeted coenzyme q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice Leptin revisited: its mechanism of action and potential for treating diabetes.Cellular insulin resistance disrupts leptin-mediated control of neuronal signaling and transcription.Liver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.Diet-induced obese mice retain endogenous leptin action.The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis.Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice Role of proopiomelanocortin neuron Stat3 in regulating arterial pressure and mediating the chronic effects of leptin Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing.JAK-STAT and feeding.Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.The Leptin Receptor Complex: Heavier Than Expected?Leptin Resistance and the Neuro-Adipose Connection.Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice.The receptive function of hypothalamic and brainstem centres to hormonal and nutrient signals affecting energy balance.Metabolic transceivers: in tune with the central melanocortin system.Leptin signaling as a therapeutic target of obesity.Hypothalamic ER stress: A bridge between leptin resistance and obesity.Hypothalamic Dysfunction in Obesity and Metabolic Disorders.Insulin action in the brain: Roles in energy and glucose homeostasis.Neotomodon alstoni mice present sex differences between lean and obese in daily hypothalamic leptin signaling.Diet-Induced Obesity and the Mechanism of Leptin Resistance.Translational Research: From Biological Discovery to Public Benefit (or Not)

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P2860

Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity

http://www.wikidata.org/entity/Q28479009

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2012 nî lūn-bûn

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Over-expression of leptin rece ...... bility to diet-induced obesity

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Over-expression of leptin rece ...... bility to diet-induced obesity

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Over-expression of leptin rece ...... bility to diet-induced obesity

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Over-expression of leptin rece ...... bility to diet-induced obesity

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Over-expression of leptin rece ...... bility to diet-induced obesity

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Over-expression of leptin rece ...... bility to diet-induced obesity

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Over-expression of leptin rece ...... bility to diet-induced obesity

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Over-expression of leptin rece ...... bility to diet-induced obesity

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Over-expression of leptin rece ...... bility to diet-induced obesity

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Christian Bjørbæk

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Joyce E Hairston

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Lihong Huo

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Sangdeuk Ha

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Sarah Greeley

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P2860

PTP1B regulates leptin signal transduction in vivo

The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity

The role of SOCS-3 in leptin signaling and leptin resistance

Divergent signaling capacities of the long and short isoforms of the leptin receptor

Central nervous system control of food intake

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Transgenic mice overexpressing leptin accumulate adipose mass at an older, but not younger, age.

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