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Down-regulating sphingolipid synthesis increases yeast lifespan

Down-regulating sphingolipid synthesis increases yeast lifespan

http://www.wikidata.org/entity/Q28480463

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Regulation of pol III transcription by nutrient and stress signaling pathways Functional loss of two ceramide synthases elicits autophagy-dependent lifespan extension in C. elegans Iron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase.Characterization of yeast mutants lacking alkaline ceramidases YPC1 and YDC1.The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.Drug synergy drives conserved pathways to increase fission yeast lifespan Six plant extracts delay yeast chronological aging through different signaling pathways Calorie restriction in mammals and simple model organisms.Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid The yeast sphingolipid signaling landscape.Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism.Statistical analysis reveals co-expression patterns of many pairs of genes in yeast are jointly regulated by interacting loci.Impact of nutrient imbalance on wine alcoholic fermentations: nitrogen excess enhances yeast cell death in lipid-limited must.Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans.Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging.Autophagy in the light of sphingolipid metabolism Interplay among Gcn5, Sch9 and mitochondria during chronological aging of wine yeast is dependent on growth conditions.Genomic profiling of fungal cell wall-interfering compounds: identification of a common gene signature.Depletion of yeast PDK1 orthologs triggers a stress-like transcriptional response.Lipid Signaling via Pkh1/2 Regulates Fungal CO2 Sensing through the Kinase Sch9.Altered Lipid Synthesis by Lack of Yeast Pah1 Phosphatidate Phosphatase Reduces Chronological Life Span.Producing human ceramide-NS by metabolic engineering using yeast Saccharomyces cerevisiae.TEAK: topology enrichment analysis framework for detecting activated biological subpathways.Reducing signs of aging and increasing lifespan by drug synergy.Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan.Activation of protein kinase C-mitogen-activated protein kinase signaling in response to inositol starvation triggers Sir2p-dependent telomeric silencing in yeast.Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function Sphingolipids contribute to acetic acid resistance in Zygosaccharomyces bailii.Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast Sphingolipids and lifespan regulation.Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.Sphingolipids and mitochondrial function, lessons learned from yeast Fpk1/2 kinases regulate cellular sphingoid long-chain base abundance and alter cellular resistance to LCB elevation or depletion.Molecular mechanisms linking the evolutionary conserved TORC1-Sch9 nutrient signalling branch to lifespan regulation in Saccharomyces cerevisiae.Lipids and cell death in yeast.Sphingolipids and mitochondrial function in budding yeast.Nonlinear fitness consequences of variation in expression level of a eukaryotic gene Assessment of crosstalks between the Snf1 kinase complex and sphingolipid metabolism in S. cerevisiae via systems biology approaches.Evolution of regulatory networks in Candida glabrata: learning to live with the human host.Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing.

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Down-regulating sphingolipid synthesis increases yeast lifespan

http://www.wikidata.org/entity/Q28480463

description

2012 nî lūn-bûn

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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2012 թվականի փետրվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Down-regulating sphingolipid synthesis increases yeast lifespan

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Down-regulating sphingolipid synthesis increases yeast lifespan

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Down-regulating sphingolipid synthesis increases yeast lifespan

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type

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Down-regulating sphingolipid synthesis increases yeast lifespan

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Down-regulating sphingolipid synthesis increases yeast lifespan

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Down-regulating sphingolipid synthesis increases yeast lifespan

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Down-regulating sphingolipid synthesis increases yeast lifespan

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Down-regulating sphingolipid synthesis increases yeast lifespan

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Down-regulating sphingolipid synthesis increases yeast lifespan

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Down-regulating sphingolipid synthesis increases yeast lifespan

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Robert C Dickson

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Xinhe Huang

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P2860

Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9

Extension of chronological life span in yeast by decreased TOR pathway signaling

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Caloric restriction delays disease onset and mortality in rhesus monkeys

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

Regulation of longevity and stress resistance by Sch9 in yeast.

Rpm2p, a protein subunit of mitochondrial RNase P, physically and genetically interacts with cytoplasmic processing bodies.

The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis.

A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling.

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