BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system
about
Harnessing Cerebrospinal Fluid Biomarkers in Clinical Trials for Treating Alzheimer's and Parkinson's Diseases: Potential and ChallengesAmyloid-β metabolism in Niemann-Pick C disease models and patients.Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's diseaseCNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.The future of blood-based biomarkers for Alzheimer's disease.Peptidome analysis of cerebrospinal fluid by LC-MALDI MSIndependent information from cerebrospinal fluid amyloid-β and florbetapir imaging in Alzheimer's diseaseThe Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target PopulationsBACE1 as a therapeutic target in Alzheimer's disease: rationale and current status.Biomarker modelling of early molecular changes in Alzheimer's disease.Truncated and modified amyloid-beta species.Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases.The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: Emergence of the Solution to an Important Unmet Need.Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.Solid-Phase Synthesis and Characterization of N-Terminally Elongated Aβ-3-x -Peptides.β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavageProfiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor.Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.Characterization of a sensitive mouse Aβ40 PD biomarker assay for Alzheimer's disease drug development in wild-type mice.Unresolved questions in Alzheimer's research: will biomarkers help?The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease
P2860
Q28072061-C15B3CBB-2B53-4467-A924-E2248A312D61Q31088092-99C35A3A-012E-4A37-8BD6-5F5E10DDC206Q33624303-0A22B460-37D0-42B5-A817-A28AD65C1975Q33735544-876F3BD7-EC6C-4BFC-B88A-193DBEE545E9Q34026317-50D171BA-4E88-4B67-A837-12ADDAD92DAEQ34374324-3C35F1BF-3783-4119-8654-D13EDF997FE0Q35119389-98BD4D6F-AA7C-4B93-B27A-5175CC319D5DQ36165011-B04DF380-524B-4C27-A8AA-89721D3EE78CQ38120669-BA028F5A-7C5C-4E2E-992E-38EBB2253DB0Q38166669-635F0E96-5269-4F38-ADB9-BE8315E52748Q38230390-0B081C10-1283-411B-8A34-0C5663F3A9DFQ38289739-5D5F25F5-DBB2-48EA-9DB9-B81A3AA733EDQ39095782-2A56B888-0129-4695-A64D-F65819CA316CQ39222469-935A1D4A-16BA-4A8F-A7E0-E51A1B52D1E2Q39341047-6D72B8D6-5AB1-4DFF-BDA2-E08A0E680C2BQ40972124-17019AD0-E0AD-459A-BFC4-8BC874DD2922Q41607465-AF00A349-E4C8-4874-B65F-B93FF6E5533DQ41993821-089E21F1-43C0-4FFA-A4BF-E7D538789C41Q42656255-1938EB2F-3956-4DD1-BD56-DE184D0A0C83Q47587631-2E7AE883-BB92-49AD-810C-13D944A38A1CQ52139105-686B16DF-6B03-49C5-815C-BDA57C248771Q53346967-EB379499-37C2-47F5-AFF9-EBEB366037DEQ59133137-055BB3FB-895D-457D-A68C-7DD549FDCFEB
P2860
BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous system
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
BACE1 inhibition induces a spe ...... in the central nervous system
@ast
BACE1 inhibition induces a spe ...... in the central nervous system
@en
BACE1 inhibition induces a spe ...... in the central nervous system
@nl
type
label
BACE1 inhibition induces a spe ...... in the central nervous system
@ast
BACE1 inhibition induces a spe ...... in the central nervous system
@en
BACE1 inhibition induces a spe ...... in the central nervous system
@nl
prefLabel
BACE1 inhibition induces a spe ...... in the central nervous system
@ast
BACE1 inhibition induces a spe ...... in the central nervous system
@en
BACE1 inhibition induces a spe ...... in the central nervous system
@nl
P2093
P2860
P50
P3181
P1433
P1476
BACE1 inhibition induces a spe ...... in the central nervous system
@en
P2093
Deborah Dhuyvetter
Fredrik Jeppsson
Herman Borghys
Johan Lundkvist
Ludovic Perrot
Marc Mercken
Maria Olsson
Mikael Gustavsson
Ulf Andreasson
Ulf Neumann
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0031084
P407
P50
P577
2012-01-01T00:00:00Z