Multi-level targeting of the phosphatidylinositol-3-kinase pathway in non-small cell lung cancer cells - Wikidata - wikimedia - TriplyDB

Multi-level targeting of the phosphatidylinositol-3-kinase pathway in non-small cell lung cancer cells

Multi-level targeting of the phosphatidylinositol-3-kinase pathway in non-small cell lung cancer cells

http://www.wikidata.org/entity/Q28480805

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Genomic profiling toward precision medicine in non-small cell lung cancer: getting beyond EGFR Genotype directed therapy in murine mismatch repair deficient tumors Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway.NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/mTOR phosphorylation.EGFR expression is associated with decreased benefit from trastuzumab in the NCCTG N9831 (Alliance) trial Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis Safety and Efficacy of Buparlisib (BKM120) in Patients with PI3K Pathway-Activated Non-Small Cell Lung Cancer: Results from the Phase II BASALT-1 Study.Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: eliminating activity by targeting at different levels Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells.Laricitrin suppresses increased benzo(a)pyrene-induced lung tumor-associated monocyte-derived dendritic cell cancer progression PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer.Tumor cell expression of vascular endothelial growth factor receptor 2 is an adverse prognostic factor in patients with squamous cell carcinoma of the lung Expression profiling of cervical cancers in Indian women at different stages to identify gene signatures during progression of the disease.The Biological Role of PI3K Pathway in Lung Cancer.Treatment effect of buparlisib, cetuximab and irradiation in wild-type or PI3KCA-mutated head and neck cancer cell lines.A novel herbal formula induces cell cycle arrest and apoptosis in association with suppressing the PI3K/AKT pathway in human lung cancer A549 cells.Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential.Inhibition of pan-class I phosphatidyl-inositol-3-kinase by NVP-BKM120 effectively blocks proliferation and induces cell death in diffuse large B-cell lymphoma.Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells.MiR-503 targets PI3K p85 and IKK-β and suppresses progression of non-small cell lung cancer.Identification of a subset of human non-small cell lung cancer patients with high PI3Kβ and low PTEN expression, more prevalent in squamous cell carcinoma.MiR-30a-5p Overexpression May Overcome EGFR-Inhibitor Resistance through Regulating PI3K/AKT Signaling Pathway in Non-small Cell Lung Cancer Cell Lines.Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS.Significance of p85 expression as a prognostic factor for patients with breast cancer.Gefitinib versus erlotinib as salvage treatment for lung adenocarcinoma patients who benefited from the initial gefitinib: A retrospective study.[Molecular pathology of the lungs. New perspectives by next generation sequencing].p85 protein expression is associated with poor survival in HER2-positive patients with advanced breast cancer treated with trastuzumab.[Research status on targeted therapy for squamous cell lung cancer].

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Multi-level targeting of the phosphatidylinositol-3-kinase pathway in non-small cell lung cancer cells

http://www.wikidata.org/entity/Q28480805

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2012 nî lūn-bûn

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2012 թուականին հրատարակուած գիտական յօդուած

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Wolfgang Hackl

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P2860

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data from 16 randomized controlled trials

Somatic mutations affect key pathways in lung adenocarcinoma

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

The phosphoinositide 3-kinase pathway

TOR, a central controller of cell growth.

Signaling by distinct classes of phosphoinositide 3-kinases

Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells

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